Absence of Stress Response in Dorsal Raphe Nucleus in Modulator of Apoptosis 1-Deficient Mice

Molecular Neurobiology
Hui ZhaoPeter T-H Wong

Abstract

Modulator of apoptosis 1 (MOAP-1) is a Bcl-2-associated X Protein (BAX)-associating protein that plays an important role in regulating apoptosis. It is highly enriched in the brain but its function in this organ remains unknown. Studies on BAX-/- mice suggested that disruption of programmed cell death may lead to abnormal emotional states. We thus hypothesize that MOAP-1-/- mice may also display stress-related behavioral differences and perhaps involved in stress responses in the brain and investigated if a depression-like trait exists in MOAP-1-/- mice, and if so, whether it is age related, and how it relates to central serotonergic stress response in the dorsal raphe nucleus. Young MOAP-1-/- mice exhibit depression-like behavior, in the form of increased immobility time when compared to age-matched wild-type mice in the forced swimming test, which is abolished by acute treatment of fluoxetine. This is supported by data from the tail suspension and sucrose preference tests. Repeated forced swimming stress causes an up-regulation of tryptophan hydroxylase 2 (TPH2) and a down-regulation of brain-derived neurotrophic factor (BDNF) in the dorsal raphe nucleus (DRN) in young wild-type (WT) control mice. In contrast, TPH2 up-regulat...Continue Reading

References

May 1, 1975·Journal of Gerontology·C L Goodrick
Mar 1, 1975·Journal of Gerontology·I Kunstyr, H G Leuenberger
Apr 24, 1997·Nature·W C DrevetsM E Raichle
Nov 11, 1998·European Journal of Pharmacology·I Hervás, F Artigas
Jan 7, 1999·Stress : the International Journal on the Biology of Stress·L G Kirby, I Lucki
Jun 9, 1999·The American Journal of Psychiatry·K S KendlerC A Prescott
Dec 11, 1999·Psychopharmacology·A Dalvi, I Lucki
Aug 25, 2001·Annual Review of Neuroscience·E J Huang, L F Reichardt
Oct 25, 2001·Proceedings of the National Academy of Sciences of the United States of America·B CzéhE Fuchs
Dec 26, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·V ArangoJ J Mann
May 15, 2002·Trends in Pharmacological Sciences·John F CryanIrwin Lucki
Jul 2, 2002·The American Journal of Psychiatry·Thomas FrodlHans-Jürgen Möller
Jan 4, 2003·Science·Diego J WaltherMichael Bader
Jan 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Glenda M MacQueenL Trevor Young
Oct 18, 2003·Biochemical Pharmacology·Diego J Walther, Michael Bader
Jan 28, 2004·Biological Psychiatry·Firas M ChamasEsther L Sabban
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Lisa M MonteggiaEric J Nestler
Dec 14, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Woong SunRonald W Oppenheim
Feb 8, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Alfredo Briones-ArandaOfir Picazo
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kuan Onn TanVictor C Yu
Dec 5, 2006·Current Opinion in Psychiatry·John F Cryan, David A Slattery
May 31, 2007·Proceedings of the National Academy of Sciences of the United States of America·Nai Yang FuVictor C Yu
Jun 26, 2007·Biological Psychiatry·Mounira BanasrRonald S Duman
Dec 14, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jonathan P GodboutRodney W Johnson
Aug 15, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jonathan G McEuenTracy L Bale
Jan 6, 2009·Annals of the New York Academy of Sciences·Galina T ShishkinaNikolay N Dygalo

❮ Previous
Next ❯

Citations

Mar 20, 2020·Current Neurovascular Research·Wei YangLixia Suo

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy
PCR
ELISA

Software Mentioned

GraphPad Prism
Ethovision XT

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis