PMID: 9664852Jul 17, 1998Paper

Absence of the adhesio interthalamica as a marker of early developmental neuropathology in schizophrenia: an MRI and postmortem histologic study

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
P J SnyderJ A Lieberman

Abstract

Several recent studies have reported an association between midline cerebral malformations (e.g., corpus callosum, cavum septum pellucidum) and schizophrenia. The authors investigated whether absence of the adhesio interthalamica (AI), a midline structure that develops in concert with prominent features of the ventricular system soon after the bridge from the late embryonic stages to early fetal life, might constitute a marker of early developmental neuropathologic changes in schizophrenia. Eighty-two patients (54 men, 28 women) with a diagnosis of first-episode schizophrenia (FES) were recruited from consecutive admissions to a psychiatric inpatient service. Fifty-two healthy control subjects (30 men, 22 women) were recruited and matched to the patient sample on distributions of sex and age. Magnetic resonance imaging studies were performed, and the presence versus absence of the AI was determined for each subject. The length and volume of the third ventricle were measured for each subject. The AI was found to be absent more often among patients with FES compared with control subjects, and patients without an observable AI also had larger third-ventricle volumes. These differences in presence or absence of the AI observed in v...Continue Reading

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Citations

Jan 13, 2006·European Psychiatry : the Journal of the Association of European Psychiatrists·José Alexandre de Souza CrippaPhilip K McGuire
Dec 16, 2000·The British Journal of Psychiatry : the Journal of Mental Science·D FannonT Sharma
Aug 1, 2008·Acta Neuropsychiatrica·Meltem CeyhanErtugrul Colak
Mar 4, 2020·Brain Structure & Function·Alireza BorgheiSepehr Sani
Feb 24, 2001·Neuroreport·C K DeutschK Gordon-Vaugh
Jan 21, 2021·Human Brain Mapping·Alireza BorgheiSepehr Sani
Jul 14, 2021·Brain Structure & Function·Andrew K WongSepehr Sani

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