PMID: 9175915Jun 1, 1997Paper

Absence of the IL-7 receptor component CDw127 indicates that gamma(c) expression alone is insufficient for IL-7 to modulate human neutrophil responses

Clinical Immunology and Immunopathology
D Girard, A D Beaulieu

Abstract

It has been proposed that neutrophils are targets for interleukin-7 (IL-7) because this cytokine was found to increase the number of murine immature neutrophils in vivo. In addition, some nonhuman myeloid cell lines were shown to express the IL-7 receptor (IL-7R). Moreover, it was recently discovered that human neutrophils constitutively express the common gamma chain (gamma(c)), known to be a component of not only IL-7R, but also IL-2R, IL-4R, IL-9R, and IL-15R. Among these, we have recently observed that IL-4 and IL-15 are neutrophil agonists. All of the above observations prompted us to study IL-7-human neutrophil interactions. In this study, we investigated potential effects of IL-7 on a range of neutrophil responses. Although we were able to confirm the presence of the gamma(c) component on human neutrophils, we report, for the first time, that these cells lack the CDw127 component of IL-7R. When studying potential modulatory effects of IL-7 on human neutrophils, we found that IL-7 does not induce respiratory burst, phagocytosis, or cytoskeletal functions and does not alter gene expression. Positive controls were included in each assay and the expected results were obtained. In addition, in contrast to IL-4 and IL-15, we f...Continue Reading

References

Jan 1, 1992·Cytometry·Z DarzynkiewiczF Traganos
Jul 17, 1992·Science·T TakeshitaK Sugamura
Apr 1, 1991·The Journal of Experimental Medicine·M R AldersonK H Grabstein
Apr 1, 1990·The Journal of Experimental Medicine·L S ParkA E Namen
Mar 1, 1989·The Journal of Experimental Medicine·P J MorrisseyS G Reed
May 1, 1989·The Journal of Allergy and Clinical Immunology·H BoeyL Borish
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G D ChazenE M Shevach
Dec 1, 1995·Journal of Leukocyte Biology·K L KomschliesR H Wiltrout
Nov 1, 1994·European Journal of Immunology·M A del PozoF Sánchez-Madrid
Jan 1, 1995·International Immunology·Y KimuraK Sugamura
Jul 1, 1994·The Journal of Experimental Medicine·T NakaraiJ Ritz
Jan 28, 1994·Cell·T KishimotoS Akira
Mar 1, 1996·Journal of Leukocyte Biology·D GirardA D Beaulieu

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Citations

Sep 23, 1998·Clinical Immunology and Immunopathology·D GirardA D Beaulieu
Jun 10, 2009·Age·Sara Ferrando-MartínezManuel Leal
Apr 29, 2000·Current Opinion in Hematology·M A Cassatella, P P McDonald
Oct 14, 2006·Annals of the Rheumatic Diseases·S A Y HartgringJ A G van Roon
Oct 22, 2009·American Journal of Respiratory Cell and Molecular Biology·Chun K WongChristopher W K Lam
Jan 6, 2001·British Journal of Nursing : BJN·N Gopee
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francesca B AielloScott K Durum
Dec 29, 1998·Human & Experimental Toxicology·P LabbéD Girard
Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martin PelletierDenis Girard
Mar 9, 2018·JCI Insight·Bruno FrancoisRichard S Hotchkiss

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