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Absence of the Lectin Activation Pathway of Complement Ameliorates Proteinuria-Induced Renal Injury

Frontiers in Immunology

Sep 23, 2019

Samy AlghadbanNigel John Brunskill

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Abstract

Proteinuria is an adverse prognostic feature in renal diseases. In proteinuric nephropathies, filtered proteins exert an injurious effect on the renal tubulointerstitium, resulting in inflammation and fibrosis. In the present study, we assessed to what extent complement activation via t...read more

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Biological Markers
Fibrosis
Inflammation
Kidney Diseases
Lectin
Laboratory mice
Pathologic Processes
Urologic Diseases
Cytokine
Poisoning/Injury
6
6
3
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Absence of the Lectin Activation Pathway of Complement Ameliorates Proteinuria-Induced Renal Injury

Frontiers in Immunology

Sep 23, 2019

Samy AlghadbanNigel John Brunskill

PMID: 31608060

DOI: 10.3389/fimmu.2019.02238

Abstract

Proteinuria is an adverse prognostic feature in renal diseases. In proteinuric nephropathies, filtered proteins exert an injurious effect on the renal tubulointerstitium, resulting in inflammation and fibrosis. In the present study, we assessed to what extent complement activation via t...read more

Mentioned in this Paper

Biological Markers
Fibrosis
Inflammation
Kidney Diseases
Lectin
6
6
3

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