Abstract
Thrombosis portends a poor prognosis in individuals with solid tumors. Constitutive expression of tissue factor (TF) by cancer cells is a key in triggering activation of coagulation and promoting aggressive tumor behavior. Though multiple myeloma (MM) is associated with a high frequency of thrombosis in the context of thalidomide and lenalidomide therapy, prognosis is not affected by its occurrence. We sought to determine the expression of TF in MM. F3 (TF gene) expression profiling was analyzed in 55 human MM cell lines (HMCL) and in 223 solid tumor cell lines obtained from GlaxoSmithKline (GSK) Cancer Cell Line Genomic Profiling Dataset. TF was not expressed in any of the 55 HMCLs studied, in sharp contrast to solid tumors, 90% of which showed TF expression. F3 expression was also absent in tumor samples from 239 MM patients. Immunohistochemistry for TF was negative, with either no or focal (1+) staining in 70/73 MM patients. Only three marrow biopsies were moderately (2+) positive either focally or diffusely, suggesting that in rare cases bone marrow microenvironment may support TF expression. General lack of TF expression by neoplastic plasma cells may explain why thrombosis is not predictive of poor outcome, and why aspiri...Continue Reading
References
Sep 28, 1999·Medicine·N LevitanA A Rimm
Sep 23, 2000·Nature·S R Coughlin
Dec 16, 2000·The New England Journal of Medicine·H T SørensenJ A Baron
Oct 21, 2004·Blood·Joanne L YuJanusz W Rak
Aug 23, 2005·Thrombosis and Haemostasis·Houria MechichePhilippe Nguyen
Feb 16, 2006·Seminars in Thrombosis and Hemostasis·Henri H Versteeg, Wolfram Ruf
Dec 15, 2006·Journal of Thrombosis and Haemostasis : JTH·M E T TesselaarS Osanto
Aug 19, 2007·Cancer Cell·Jonathan J KeatsP Leif Bergsagel
Sep 25, 2007·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Maurizio ZangariGuido Tricot
Oct 20, 2007·Blood·Elena M EgorinaBjarne Østerud
Dec 11, 2007·Leukemia & Lymphoma·Ruben NiesvizkyMorton Coleman
Feb 5, 2008·Leukemia Research·Adriana M W van MarionFrank W G Leebeek
Jun 4, 2008·Thrombosis and Haemostasis·Helene F S NegaardPer Morten Sandset
Jul 23, 2008·Seminars in Thrombosis and Hemostasis·Jeffrey I Zwicker
May 9, 2009·American Journal of Hematology·Kazuyuki Shimizu, Junji Itoh
Sep 10, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carla Boccaccio, Paolo M Comoglio
Sep 10, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Raj S KasthuriNigel Mackman
Sep 16, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anna Falanga, Marina Marchetti
Nov 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maurizio ZangariLouis Fink
Dec 8, 2009·Blood·Rekha PalSuzanne Lentzsch
Nov 9, 2010·Thrombosis and Haemostasis·Johannes J A AuwerdaFrank W G Leebeek
Feb 2, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio PalumboMario Boccadoro
Apr 7, 2011·Leukemia·W-J ChngR Fonseca
Citations
Mar 5, 2013·Journal of the American Chemical Society·John E DeLorbeLarry E Overman
Mar 5, 2013·Journal of the American Chemical Society·Salman Y Jabri, Larry E Overman
Oct 9, 2013·Journal of Medicinal Chemistry·Fanny L CherblancMatthew J Fuchter
May 15, 2013·Leukemia·J G HarbD Perrotti
Jun 20, 2013·Leukemia·J A McCubreyA M Martelli
Mar 8, 2013·Leukemia·T BarbuiA Tefferi
Jul 25, 2012·Nature Reviews. Cancer·Thomas O'HareMichael W Deininger
May 23, 2013·PloS One·Yu IsozumiTakatoshi Koyama
Nov 19, 2013·Leukemia·U KaindlR Panzer-Grümayer
Oct 26, 2013·Leukemia·M A Kharfan-DabajaL J N Cooper
Nov 19, 2014·Hämostaseologie·C Dicke, F Langer
Dec 15, 2012·Thrombosis Research·Kathryn DateLeigh A Madden
Apr 2, 2015·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Heyu HuangDengju Li
Jun 27, 2013·Blood·Julia E Geddings, Nigel Mackman
Feb 5, 2014·Thrombosis Research·Gabriela Cesarman-MausRafael Fonseca
May 28, 2016·Expert Review of Hematology·Despina FotiouEvangelos Terpos
Aug 28, 2016·Thrombosis Research·Jessica HallAnthony Maraveyas
May 10, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rafael FonsecaEsteban Braggio