Absent event-related potential (ERP) word repetition effects in mild Alzheimer's disease.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
John M OlichneyM Kutas

Abstract

We hypothesized that an ERP word repetition paradigm, which reliably elicits and modulates the P600 and N400 components, would be particularly sensitive to the memory deficits and altered synaptic plasticity in mild Alzheimer's disease (AD). The P600 (a late positive component, or 'LPC'), and the N400, are sensitive indices of memory encoding and semantic processing, respectively. We studied 11 patients with mild AD (mean MMSE=22.9) and 11 elderly (mean age=77.1) normal controls (NC) on a paradigm in which semantically 'congruous' category statement/exemplar pairs (50%) and 'incongruous' category statement/non-exemplar pairs (50%) repeat at 10-140 s intervals. A minimum of 19 channels ERP data were recorded and submitted to split-plot ANOVAs. Normal ERP data showed: (1) a significant word repetition effect for congruous words, with a wide-spread late positivity between approximately 300 and 800 ms post-stimulus (P600) that is larger for New than Old words; (2) a significant N400 repetition effect for incongruous words, with a right posterior negativity that is reduced for Old relative to New words. By contrast, neither of these word repetition effects was reliably present in the mild AD group. Good group discrimination was achi...Continue Reading

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Citations

Mar 13, 2012·Experimental Aging Research·Cristina SaavedraEla I Olivares
Apr 23, 2010·Brain : a Journal of Neurology·John M OlichneyRandi Hagerman
Nov 27, 2010·Dementia and Geriatric Cognitive Disorders·Alan GevinsRuth O'Hara
Jul 9, 2009·Journal of Cognitive Neuroscience·Christian DobelPienie Zwitserlood
Jun 2, 2011·International Journal of Alzheimer's Disease·Roberta LizioClaudio Babiloni
Aug 20, 2014·Journal of Neurodevelopmental Disorders·Jim GrigsbyJin-Chen Yang
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May 8, 2016·Brain and Language·Natalya KaganovichCourtney Rowland
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May 30, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jin-Chen YangJohn M Olichney
Oct 23, 2018·Current Alzheimer Research·Cassandra MorrisonFrank Knoefel
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Mar 15, 2018·Schizophrenia Research and Treatment·Lâle Battal MerletMilena Kostova
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Feb 22, 2018·Journal of Clinical and Experimental Neuropsychology·Lucas S BrosterYang Jiang
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Sep 18, 2020·Behavioural Brain Research·Elizabeth R PaitelKristy A Nielson
Apr 17, 2021·Journal of Speech, Language, and Hearing Research : JSLHR·Alexandre ChauvinNatalie A Phillips

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