Absolute bioavailability of testosterone after oral administration of testosterone-undecanoate and testosterone

European Journal of Drug Metabolism and Pharmacokinetics
U TäuberH Matthes

Abstract

The plasma levels of testosterone (T) were measured after oral administration of 25 mg T and 40 mg testosterone-undecanoate (TU) in a group of young women by a specific radioimmunoassay. Plasma levels were compared to those after intravenous administration of 1.5 micrograms testosterone/kg to another group of young women for determination of absolute bioavailability. Due to the high metabolic clearance rate of 24.5 ml/min/kg absolute systemic availability of free testosterone was calculated to 3.56 +/- 2.45%. Oral administration of testosterone undecanoate leads only to an absolute testosterone bioavailability of 6.83 +/- 3.32%.

References

Apr 1, 1977·European Journal of Clinical Investigation·E NieschlagE J Wickings
Nov 1, 1979·European Journal of Clinical Pharmacology·H FreyJ Falch
Jan 1, 1978·Hormone Research·P R DaggettJ D Nabarro
Nov 10, 1967·Deutsche medizinische Wochenschrift·J Tamm
Aug 1, 1984·Clinical Endocrinology·J A CantrillD C Anderson

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Citations

May 6, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·John E Morley, H Mitchell Perry
Jan 14, 2005·Journal of Clinical Pharmacology·Sonia DavisonSusan Davis
Mar 31, 2004·Clinical Endocrinology·S KelleherD J Handelsman
Oct 15, 2013·Drug Testing and Analysis·G ForsdahlG Gmeiner
Sep 1, 2014·Clinical Pharmacology in Drug Development·Håkan OlssonLars Grundemar
Jan 7, 2015·British Journal of Pharmacology·Michael N PastoreMichael S Roberts
Dec 1, 2010·Toxicological Research·Sang-Hee JeongHa Jung Sung
Oct 2, 2014·The AAPS Journal·Jennica L Zaro
Aug 1, 2010·Hormone Molecular Biology and Clinical Investigation·Jean-Pierre RaynaudJean Gardette
Feb 28, 2008·The Journal of Clinical Endocrinology and Metabolism·Peter Y LiuChristina Wang
Apr 7, 2020·Expert Opinion on Drug Metabolism & Toxicology·Jenna L Yager, Peter L Anderson
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Arno W F T TooriansDavid J Handelsman
Feb 17, 2005·The Journal of Clinical Endocrinology and Metabolism·John K Amory, William J Bremner
May 8, 2020·International Journal of Molecular Sciences·Milica MarkovicArik Dahan
Oct 16, 2018·Medicinal Research Reviews·Milica MarkovicArik Dahan
Nov 6, 2018·Pharmaceutics·Milica MarkovicArik Dahan
Oct 22, 2019·Future Medicinal Chemistry·Arik DahanShimon Ben-Shabat
Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Atheer ZgairPavel Gershkovich
Aug 31, 2020·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Mari DaviesNenad Manevski
Jul 12, 2011·Analytica Chimica Acta·Jeroen C W RijkMichel W F Nielen
Mar 19, 2021·Drug Testing and Analysis·Sara Amalie SolheimYvette Dehnes
Sep 1, 2021·Pharmaceutical Research·Sifei HanNatalie Trevaskis

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