PMID: 15247555Jul 13, 2004Paper

Absolute CD4 vs. CD4 percentage for predicting the risk of opportunistic illness in HIV infection

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Kelly A GeboRichard D Moore

Abstract

Current guidelines recommend consideration of CD4 cell percentage as well as CD4 cell count in therapeutic decisions. The relative value of CD4 cell count compared with CD4 cell percentage in predicting risk of AIDS-defining illnesses (ADIs) in the post-HAART (highly active antiretroviral therapy) era is unknown. Data from an observational clinical cohort of adult HIV-infected patients were used to assess the risk of developing an ADI associated with specific absolute CD4 counts (CD4) and CD4%'s (CD4%) using all CD4-CD4% pairs obtained after January 1996. The incidence of developing an ADI was assessed over a maximum of 6 months after the CD4-CD4% pair was obtained. Using multivariable negative binomial regression, the incidence rate ratio (IRR) for developing an ADI by CD4 and CD4% categories was computed. A total of 15,736 CD4-CD4% pairs from 2185 patients who developed 608 ADIs was analyzed. The IRR for developing an ADI by absolute CD4 was 17.9 (95% CI: 13.2, 24.4) events/100 person-years for <50 cells/mm, 6.2 (95% CI: 4.4, 7.9) for 50-100 cells/mm, and 2.7 (95% CI: 1.9, 4.0) for 100-200 cells/mm, compared with the referent stratum of 200-350 cells/mm. Without adjustment for absolute CD4, the IRR was 14.4 (95% CI: 9.3,22.6)...Continue Reading

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Citations

Jun 26, 2009·AIDS Research and Human Retroviruses·Mohammad A ChaudharyElamin Elbasha
Jan 27, 2012·The Journal of Infectious Diseases·Mark GompelsUNKNOWN UK Collaborative HIV Cohort (UK CHIC) Study (Appendix)
Oct 2, 2008·HIV Medicine·B G GazzardUNKNOWN BHIVA Treatment Guidelines Writing Group
Aug 19, 2006·AIDS Research and Therapy·Yasmin PirzadaHaig Donabedian
Mar 31, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cassidy W ClaassenGregory D Kirk
Jan 25, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Christopher J HoffmannUNKNOWN IeDEA Southern Africa Collaboration
Jan 1, 2006·Current Opinion in HIV and AIDS·Andrew N Phillips, Jens D Lundgren
Oct 16, 2010·Journal of Immunological Methods·Denise M O'HaraVirginia Litwin
Nov 9, 2006·Statistics in Medicine·Neal AlexanderSimon Brooker
Apr 24, 2014·Tropical Medicine & International Health : TM & IH·Madalitso MaliwichiEric D McCollum
Aug 30, 2008·HIV Clinical Trials·Kit N SimpsonHenrik W Finnern
Mar 15, 2018·Journal of the International Association of Providers of AIDS Care·Henry AnyimaduSharon Mannheimer
Dec 6, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ronald J BoschConstance A Benson
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Sep 15, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Adam TrickeyUNKNOWN Antiretroviral Therapy Cohort Collaboration (ART-CC)

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