Absolute Change in High-Sensitivity Cardiac Troponin I at Three Hours After Presentation is Useful for Diagnosing Acute Myocardial Infarction in the Emergency Department.

Annals of Laboratory Medicine
Jong Won KimHyun Joong Kim

Abstract

A rise and/or fall in cardiac troponin value with at least one value above the 99th percentile upper reference limit is essential for acute myocardial infarction (AMI) diagnosis. We evaluated the clinical usefulness of serial high-sensitivity cardiac troponin I (hs-cTnI) measurements in AMI diagnosis, in terms of the predictability of absolute and relative changes. For this retrospective, forward observational study, we enrolled 281 patients older than 18 years who presented with chest pain at the emergency department (ED) between August 2015 and December 2016. The patients were grouped as AMI and non-AMI, and 73 (26%) were diagnosed as having AMI. Hs-cTnI (Abbott Diagnostics, Abbott Park, IL, USA) was measured at presentation and 3 hours later. We assessed the diagnostic performance of the absolute and relative changes in hs-cTnI. The cut-off values to predict AMI were 16.2 ng/L and 42.1% for the absolute and relative hs-cTnI changes, respectively. The area under the curve of hs-cTnI for AMI diagnosis was larger for absolute changes than for relative changes [0.96 (95% confidence interval [CI], 0.92-0.98) vs 0.89 (95% CI, 0.85-0.93)] (P=0.014). The absolute hs-cTnI change at 3 hours after presentation was superior to the relat...Continue Reading

References

Aug 28, 2009·The New England Journal of Medicine·Tobias ReichlinChristian Mueller
Aug 6, 2010·European Heart Journal·Kristian ThygesenUNKNOWN Study Group on Biomarkers in Cardiology of the ESC Working Group on Acute Cardiac Care
Dec 21, 2010·European Heart Journal·S AgewallH Katus
Dec 29, 2011·JAMA : the Journal of the American Medical Association·Till KellerStefan Blankenberg
Jun 23, 2012·European Heart Journal·Kristian ThygesenUNKNOWN Study Group on Biomarkers in Cardiology of ESC Working Group on Acute Cardiac Care
Jul 23, 2013·The American Journal of Medicine·Affan IrfanChristian Mueller
Apr 4, 2015·The American Journal of Medicine·Maria Rubini GimenezChristian Mueller
Nov 9, 2016·American Heart Journal·Karin WildiChristian Mueller
Feb 12, 2017·Internal and Emergency Medicine·Pankaj GargPhilip Haaf
Nov 8, 2018·European Heart Journal·Kristian Thygesen
Jan 9, 2019·Clinical Chemistry·Christian MuellerTobias Reichlin
Mar 12, 2019·Circulation·Janani RangaswamiUNKNOWN American Heart Association Council on the Kidney in Cardiovascular Disease and Council on Clinical Cardiology
Jun 22, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tomonori SugiuraNobuyuki Ohte
Jul 10, 2019·Journal of Emergency Nursing : JEN : Official Publication of the Emergency Department Nurses Association·Andi L Foley
Oct 2, 2019·Expert Review of Cardiovascular Therapy·Gerald FitzgeraldThomas J Kiernan
Oct 28, 2019·Swiss Medical Weekly·Danielle Menosi GualandroChristian Müller

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