Absolute measurements of radiation damage in nanometer-thick films.

Radiation Protection Dosimetry
Elahe Alizadeh, Léon Sanche

Abstract

The problem of absolute measurements of radiation damage in films of nanometer thicknesses is addressed. Thin films of DNA (∼2-160 nm) are deposited onto glass substrates and irradiated with varying doses of 1.5-keV X-rays under dry N(2) at atmospheric pressure and room temperature. For each different thickness, the damage is assessed by measuring the loss of the supercoiled configuration as a function of incident photon fluence. From the exposure curves, the G-values are deduced, assuming that X-ray photons interacting with DNA deposit all of their energy in the film. The results show that the G-value (i.e. damage per unit of deposited energy) increases with film thickness and reaches a plateau at 30±5 nm. This thickness dependence provides a correction factor to estimate the actual G-value for films with thicknesses <30 nm thickness. Thus, the absolute values of the damage can be compared with that of films of any thickness under different experimental conditions.

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Citations

Feb 19, 2013·The Journal of Physical Chemistry Letters·Elahe AlizadehLéon Sanche
Nov 5, 2015·The Journal of Physical Chemistry Letters·Stefanie VogelIlko Bald
Nov 2, 2016·Radiation Research·Surakarn ChoofongJ Richard Wagner
Mar 1, 2018·Journal of Synchrotron Radiation·Dominika BorekZbyszek Otwinowski
Jul 1, 2014·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Elahe Alizadeh, Léon Sanche

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