PMID: 8161962Feb 1, 1994Paper

Absolute measurements of total-body calcium using prompt gamma neutron analysis and internal chlorine standardization: results in renal patients

Physiological Measurement
C J EvansA J Williams

Abstract

Measurement of total-body calcium (TBCa) is important in the study of several medical conditions. Neutron activation analysis (NAA) is sufficiently precise for serial measurements, but in order to provide single, absolute determinations of TBCa, it requires a correction for body habitus. A method is described for the absolute determination of TBCa by comparing the total-body chlorine, obtained by NAA, with that obtained by stable bromine dilution. The method is applied to a group of thirty patients who had been treated for chronic renal failure, and significant differences are found between measured values of TBCa and those predicted for 'normal' healthy subjects. The overall experimental error in the absolute determination of TBCa is estimated to be 8%, for a dose equivalent of 3.1 mSv (based on skin dose, and a quality factor of 10 for neutrons).

References

May 1, 1989·Physics in Medicine and Biology·P Tothill
Aug 1, 1987·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·R A SiwekC B Oxby
Nov 1, 1985·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·S H Cohn, R M Parr
Mar 1, 1983·Physics in Medicine and Biology·N S KennedyP Tothill
Jun 1, 1953·The Journal of Clinical Investigation·J L GAMBLEL E FARR

Citations

May 7, 1998·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·C J EvansF al-Agel
Nov 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·J R SpeakmanX Lambin
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·L J VittT A Titus
Jun 24, 2000·Annals of the New York Academy of Sciences·W D Morgan

Related Concepts

Calcium
Chlorine
Kidney Failure, Chronic
Neutron Activation Analysis

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