Absolute monocyte and lymphocyte count prognostic score for patients with gastric cancer

World Journal of Gastroenterology : WJG
Wan Kyu EoHeung Yeol Kim

Abstract

To measure the prognostic significance of absolute monocyte count/absolute lymphocyte count prognostic score (AMLPS) in patients with gastric cancer. We retrospectively examined the combination of absolute monocyte count (AMC) and absolute lymphocyte count (ALC) as prognostic variables in a cohort of 299 gastric cancer patients who underwent surgical resection between 2006 and 2013 and were followed at a single institution. Both AMC and ALC were dichotomized into two groups using cut-off points determined by receiving operator characteristic curve analysis. An AMLPS was generated, which stratified patients into three risk groups: low risk (both low AMC and high ALC), intermediate risk (either high AMC or low ALC), and high risk (both high AMC and low ALC). The primary objective of the study was to validate the impact of AMLPS on both disease-free survival (DFS) and overall survival (OS), and the second objective was to assess the AMLPS as an independent prognostic factor for survival in comparison with known prognostic factors. Using data from the entire cohort, the most discriminative cut-off values of AMC and ALC selected on the receiver operating characteristic curve were 672.4/μL and 1734/μL for DFS and OS. AMLPS risk group...Continue Reading

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Citations

Dec 7, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hiroko MachidaKoji Matsuo
Nov 17, 2016·Oncotarget·Kelli A ConnollyScott A Gerber
Dec 6, 2018·American Journal of Hematology·Moritz BinderShaji K Kumar

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