Absolute quantitation of myocardial blood flow with (201)Tl and dynamic SPECT in canine: optimisation and validation of kinetic modelling.

European Journal of Nuclear Medicine and Molecular Imaging
H IidaHiroshi Watabe

Abstract

201Tl has been extensively used for myocardial perfusion and viability assessment. Unlike 99mTc-labelled agents, such as 99mTc-sestamibi and 99mTc-tetrofosmine, the regional concentration of 201Tl varies with time. This study is intended to validate a kinetic modelling approach for in vivo quantitative estimation of regional myocardial blood flow (MBF) and volume of distribution of 201Tl using dynamic SPECT. Dynamic SPECT was carried out on 20 normal canines after the intravenous administration of 201Tl using a commercial SPECT system. Seven animals were studied at rest, nine during adenosine infusion, and four after beta-blocker administration. Quantitative images were reconstructed with a previously validated technique, employing OS-EM with attenuation-correction, and transmission-dependent convolution subtraction scatter correction. Measured regional time-activity curves in myocardial segments were fitted to two- and three-compartment models. Regional MBF was defined as the influx rate constant (K(1)) with corrections for the partial volume effect, haematocrit and limited first-pass extraction fraction, and was compared with that determined from radio-labelled microspheres experiments. Regional time-activity curves responded...Continue Reading

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Citations

May 8, 2009·European Journal of Nuclear Medicine and Molecular Imaging·M PissarekN Schramm
Aug 19, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Giovanni Lucignani, Alberto Cuocolo
Jun 30, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Moshe BocherLana Volokh
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