Absolute Quantitative Evaluation of 67Ga Scintigraphy in Lupus Nephritis

Clinical Nuclear Medicine
Shih-Chuan TsaiWan-Yu Lin

Abstract

Renal biopsy is crucial for management of lupus nephritis. However, it is invasive and can cause bleeding and infection. In our previous study, we developed a semiquantitative method for gallium renal imaging and demonstrated a good correlation between the left kidney-to-spine ratio (K/S ratio) and the results of renal biopsy. However, the accuracy of left K/S ratio is compromised by the variation of spinal gallium uptake, especially in patients with extraordinarily high or low gallium uptakes in the spine. In this study, we developed an absolute quantitative method and compared the results of quantitative gallium images, semiquantitative gallium images, visual methods, and renal biopsies. Thirty-four patients with lupus nephritis were enrolled and underwent renal biopsy to determine activity index (AI) and chronicity index. A delayed 48-hour gallium scan was also performed and interpreted by visual, semiquantitative, and absolute quantitative methods. For absolute quantitative analysis, a standard solution with activities of approximately 555 KBq (15 μCi) was prepared and poured into a 5-mL tube, which was placed close to the patient. ROIs were drawn around the outer edge of the left kidney as well as around the outer edges of...Continue Reading

References

Apr 1, 1988·Clinical Nuclear Medicine·R P SpencerH Kassamali
Apr 1, 1984·Seminars in Nuclear Medicine·B C LentleR Ensslen
Mar 20, 1998·Scandinavian Journal of Rheumatology·W Y LinS J Wang
Aug 26, 1998·Clinical Nuclear Medicine·W Y LinS J Wang
Dec 6, 2000·European Journal of Nuclear Medicine·W Y LinS J Wang
Dec 13, 2005·Lupus·G ContrerasH Garcia Estrada
Oct 25, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michael ZappitelliIndra R Gupta
Jul 17, 2009·Current Rheumatology Reports·Lena Das, Hermine I Brunner
Nov 20, 2009·Revista española de medicina nuclear·I Asensio NoguésA Mateo Navarro
Feb 4, 2010·Clinical Reviews in Allergy & Immunology·Joyce Reyes-ThomasChaim Putterman
Mar 30, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Adriana I JoaquimEmmanuel A Burdmann
Aug 9, 2011·Clinical and Experimental Nephrology·Keiko YasudaTerumasa Hayashi
Sep 21, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Abdulkareem AlsuwaidaHala Kfoury
Sep 15, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Giovanna Giannico, Agnes B Fogo
Apr 9, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·María Teresa Torres-SalidoJosep Ordi-Ros
Jun 28, 2014·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Tetsu AkimotoEiji Kusano
Oct 28, 2014·Clinical and Experimental Immunology·Jack HutchesonTianfu Wu

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