Absorbable magnesium-based stent: physiological factors to consider for in vitro degradation assessments

Regenerative Biomaterials
Juan WangNan Huang

Abstract

Absorbable metals have been widely tested in various in vitro settings using cells to evaluate their possible suitability as an implant material. However, there exists a gap between in vivo and in vitro test results for absorbable materials. A lot of traditional in vitro assessments for permanent materials are no longer applicable to absorbable metallic implants. A key step is to identify and test the relevant microenvironment and parameters in test systems, which should be adapted according to the specific application. New test methods are necessary to reduce the difference between in vivo and in vitro test results and provide more accurate information to better understand absorbable metallic implants. In this investigative review, we strive to summarize the latest test methods for characterizing absorbable magnesium-based stent for bioabsorption/biodegradation behavior in the mimicking vascular environments. Also, this article comprehensively discusses the direction of test standardization for absorbable stents to paint a more accurate picture of the in vivo condition around implants to determine the most important parameters and their dynamic interactions.

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Citations

Aug 13, 2015·Scientific Reports·Rong-Chang ZengEn-Hou Han
Aug 3, 2016·Regenerative Biomaterials·Tao HuangYong Han
May 26, 2016·Journal of Biomedical Materials Research. Part a·Jian ZhangGuangyin Yuan
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Nov 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hao ZhangYunbing Wang
Oct 3, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yuehua ZhouYuping Chen

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x-ray spectroscopy

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