Absorbable mesh sling prevents radiation-induced bowel injury during "sandwich" chemoradiation for rectal cancer

Archives of Surgery
B E WaddellN J Petrelli

Abstract

Absorbable mesh slings can prevent radiation-induced bowel injury when adjuvant pelvic radiotherapy is given in the early postoperative period. We hypothesized that the mesh sling technique is similarly effective during "sandwich" sequence adjuvant chemoradiation. Retrospective review. Tertiary care comprehensive cancer center. Nonrandomized series of 19 consecutive patients who underwent abdominoperineal resection and received postoperative sandwich sequence chemoradiation at Roswell Park Cancer Institute, Buffalo, NY, between January 1994 and September 1999. Twelve patients had an absorbable mesh sling placed at the completion of abdominoperineal resection. Seven patients did not have an absorbable mesh sling placed. Radiotherapy dose and gastrointestinal toxic effects. All 12 patients in the "mesh" group were able to receive full-dose radiotherapy with tumor bed boost (total dose, 54 Gy, 11 patients; 59.4 Gy, 1 patient). Only 3 of 7 patients in the "no mesh" group were able to receive a tumor bed boost (total dose, 46.8 Gy, 1 patient; 50.4 Gy, 3 patients; 54 Gy, 3 patients). Acute gastrointestinal toxic effects were minimal in the mesh group (grade 1, 10 patients; grade 2, 2 patients) compared with the no mesh group (grade 2...Continue Reading

Citations

Jan 25, 2013·World Journal of Gastroenterology : WJG·Abobakr K ShadadLaurence J Egan
Jul 30, 2005·International Journal of Colorectal Disease·Matthias Guckenberger, Michael Flentje
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Mar 13, 2014·Diseases of the Colon and Rectum·Raymond Yap, David Lloyd

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