Absorbed dose profiles for (32)P, (90)Y, (188)Re, (177)Lu, (153)Sm and (169)Er: radionuclides used in radiosynoviortheses treatment

Revista española de medicina nuclear
M TorresM A Montano Delgado

Abstract

The main objective of this paper was to obtain the absorbed dose profiles for radionuclides of frequent or potential use in radiosynoviortheses. These profiles reveal the absorbed dose per activity of injected radionuclide (Gy/h*MBq) in the synovial membrane and the articular cartilage. The researched radionuclides were (32)P, (90)Y, (188)Re, (177)Lu, (153)Sm and (169)Er. The therapeutic range of each radionuclides in synovial tissue were also calculated. This range determines the synovial thickness that can be sufficiently irradiated and thus successfully treated. The S values for the synovial membrane and articular cartilage were calculated using as a model a cylinder with the source uniformly distributed in its volume. The synovial membrane was simulated varying the radius of the cylinder (from 0.5cm to 9cm) and its height (from 0.01cm to 0.04cm). The area in the base of the cylinder represents different sizes of the synovial surface (small, medium and large joints). The height of the cylinder represents different stages of the progression of the rheumatoid arthritis. The same model was used to simulate the articular cartilage but, the source was uniformly distributed into a cylindrical slab (0.01cm height and 1cm of radius....Continue Reading

References

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Citations

Jan 23, 2014·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Andrew FenwickJohn Keightley
Sep 17, 2014·Cancer Biotherapy & Radiopharmaceuticals·Andras PolyakLajos Balogh
Dec 20, 2015·Cancer Biotherapy & Radiopharmaceuticals·Andras PolyakLajos Balogh
Feb 13, 2018·Journal of Labelled Compounds & Radiopharmaceuticals·Sudipta ChakrabortyAshutosh Dash
Oct 11, 2017·Health Physics·Mirta Barbara Torres BerdeguezAdemir Xavier da Silva
Jul 21, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sudipta ChakrabortyAshutosh Dash
May 12, 2020·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Mirta Bárbara Torres BerdeguezAdemir Xavier da Silva
Jul 15, 2021·International Journal of Radiation Biology·Seyed Alireza JavadiniaRachna Kapoor

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