May 20, 2003

Absorption and distribution of 5-aminosalicylic acid from its chitosan capsule degraded by colon bacteria-released enzymes in rats

Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA
Guo-feng LiZhi-liang Chen


To examine the absorption and distribution of 5-aminosalicylic acid (5-ASA) in rat colon after oral administration of its chitosan capsule. 5-ASA in chitosan capsules (4.8 mg per 3 capsules) were administered orally in rats via a polyethylene cannula under light ether anesthesia. The rats in control group were given 1 ml 5-ASA carboxymethyl cellulose suspension (4.8 mg). Blood samples were obtained from the rat hearts and the colon tissues sampled at a given interval to measure the concentration of 5-ASA by HPLC. The area under the curve (AUC(0-12)) in the serum samples of chitosan capsule group was 0.62 times that of the control group, while in the colon tissue, the AUC(0-12) of chitosan capsule group was as much as 3.62 times that of the control group. The chitosan capsule may be a useful carrier of 5-ASA for colon-specific delivery.

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Mentioned in this Paper

Area Under Curve
Taenia Coli
Body Parts - Cannula
Specimen Type - Cannula
Enzymes, antithrombotic
Microbial Anatomical Capsule Structure
Process of Absorption
Etherum, ether, Homeopathic preparation

About this Paper

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