PMID: 3762332Sep 1, 1986Paper

Absorption and distribution of deuterium-labeled trans- and cis-11-octadecenoic acid in human plasma and lipoprotein lipids

Lipids
E A EmkenR M Gulley

Abstract

Triglycerides of deuterium-labeled trans-11-, trans-11-cis-11- and cis-9-octadecenoic acid (11t-18:1-2H, 11c-18:1-2H) were simultaneously fed to two young adult male subjects. Plasma lipids from blood samples collected periodically for 48 hr were analyzed by gas chromatography-mass spectroscopy. The results indicate the delta 11-18:1-2H acids and 9c-18:1-2H were equally well absorbed; relative turnover rates were higher for the delta 11-18-1-2H acids in plasma triglycerides; incorporation of the delta 11-18:1-2H acids into plasma phosphatidylcholine was similar to 9c-18:1-2H, but distribution at the 1- and 2-acyl positions was substantially different; esterification of cholesterol with 11t-18:1 was extremely low; chain shortening of the delta 11-18:1-2H acids was 2-3 times greater than for 9c-18:1-2H; no evidence for desaturation or elongation of the 18:1-2H acids was detected; and a 40% isotopic dilution of the 18:1-2H acids in the chylomicron triglyceride fraction indicated the presence of a substantial intestinal triglyceride pool. Based on our present knowledge, these metabolic results for delta 11-18:1 acids present in hydrogenated oils and animal fats indicate that the delta 11 isomers are no more likely than 9c-18:1 to c...Continue Reading

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Citations

Aug 1, 1992·Lipids·B N MarboisJ Edmond
Apr 11, 2000·Lipids·R O AdlofE A Emken
Jan 15, 1999·Atherosclerosis·M M van Greevenbroek, T W de Bruin
Aug 23, 2006·The British Journal of Nutrition·C Murray Skeaff, Sonya Gowans
Jan 1, 1996·Nutrition Research Reviews·M I Gurr
Sep 27, 2005·Critical Reviews in Food Science and Nutrition·Tilak R DhimanAmy L Ure
Nov 26, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Catherine J FieldDonna Vine
Jan 16, 1998·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J T Brenna
Feb 17, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Rita Kohen AvramogluKhosrow Adeli
Mar 17, 2000·The Journal of Nutrition·J E SantoraK L Roehrig
Sep 1, 1992·Zeitschrift für Ernährungswissenschaft·H Steinhart, A Pfalzgraf
Aug 29, 2002·The American Journal of Clinical Nutrition·Anu M TurpeinenJ Mikko Griinari
Oct 6, 2021·Lipids·Susana P AlvesMichael E R Dugan

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