Absorption and distribution of tea catechin, (-)-epigallocatechin-3-gallate, in the rat

Journal of Nutritional Science and Vitaminology
K Nakagawa, T Miyazawa

Abstract

To investigate the absorption and metabolism of an anticarcinogenic tea catechin, (-)-epigallocatechin-3-gallate (EGCg), in rats, a newly developed chemiluminescence-detection high-performance liquid chromatography (CL-HPLC) method was employed and the EGCg concentrations in blood plasma, liver, brain, small intestinal mucosa and colon mucosa were determined before and after EGCg administration. The recovery of EGCg, extracted consecutively with ethyl acetate and methanol, was 86.1% from plasma and 64.5-74.2% from the tissue samples. The EGCg concentrations of plasma and tissue samples from the control rat (before EGCg administration) were all below the detection limit (< 0.002 nmol/mL, 0.002 nmol/g), but 60 min after a single oral administration of EGCg (500 mg/kg body weight), the levels increased, reaching 12.3 nmol/mL in plasma, 48.4 nmol/g in liver, 0.5 nmol/g in brain, 565 nmol/g in small intestinal mucosa and 68.6 nmol/g in colon mucosa. The EGCg levels found in the tissues corresponded to 0.0003-0.45% of ingested EGCg. The results indicate that tea catechin, EGCg, is absorbed from the digestive tract, with the intestinal mucosa the most enriched of the organelles. This may explain the potent antioxidant function of EGCg...Continue Reading

Citations

Oct 8, 2003·BioFactors·Hironori TsuchiyaHiroshi Takeuchi
Dec 19, 2001·Archives of Biochemistry and Biophysics·Guangjun NieBaolu Zhao
Feb 19, 2000·Biochemical and Biophysical Research Communications·I AbeT Ono
Oct 5, 2006·Analytical and Bioanalytical Chemistry·Xiaofeng ZhengGenxi Li
Sep 8, 2006·Biogerontology·Keiko UnnoMinoru Hoshino
Jun 19, 2012·Molecular Neurobiology·Sebastian SchafferGunter P Eckert
Oct 21, 2011·Genes & Nutrition·Sebastian Schaffer, Barry Halliwell
Nov 4, 2000·Atherosclerosis·J RuidavetsJ Cabanis
Mar 12, 2003·Mutation Research·Joshua D Lambert, Chung S Yang
Dec 7, 2002·Progress in Lipid Research·Anita ChughJung B Gupta
Dec 12, 2001·Neurochemistry International·Chien Yuan PanAaron P Fox
Jul 23, 2003·The Journal of Nutritional Biochemistry·Daniel G RaederstorffPeter Weber
Mar 22, 2002·The Lancet Oncology·A J GescherW P Steward
Oct 16, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·H V Nobre JúniorV S N Rao
Aug 20, 2011·The British Journal of Nutrition·Tsuyoshi GotoSatoshi Nagaoka
Sep 1, 2005·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Raymond CooperDorothy M Morré
Aug 31, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R Jeroen Pasterkamp, Joost Verhaagen
Feb 11, 2004·Neuro-oncology·Domenico DidianoMichael A Grotzer
Feb 23, 2011·International Journal of Molecular Sciences·Jiang-Hua WangFei Cai
Nov 8, 2011·Surgical Neurology International·Anthony L PetragliaJulian E Bailes
Mar 3, 2004·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yoshiyuki YodaTadakatsu Shimamura
Feb 17, 2001·Biochemical and Biophysical Research Communications·I AbeH Noguchi
Jan 26, 2002·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·W H ZhaoT Shimamura
Mar 1, 2007·Expert Opinion on Drug Discovery·Suresh Kumar GuptaShyam Sunder Agrawal
Feb 10, 2011·Journal of Drug Targeting·Yaw-Bin HuangJia-You Fang
Apr 21, 2006·Journal of Pharmaceutical Sciences·Kai On ChuChi Pui Pang
Oct 31, 2003·Journal of Cellular Biochemistry·Anthony PilorgetRichard Béliveau
Jun 1, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·H-H Sherry Chow, Iman A Hakim
May 27, 2008·Brain Research Bulletin·Belmira Lara da Silveira Andrade da CostaNeville N Osborne
Feb 19, 2008·The Journal of Nutritional Biochemistry·Abdul M HaqueOsamu Shido

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