PMID: 8610524Jan 1, 1995Paper

Absorption and excretion of iodixanol after intragastric administration to rats

Acta Radiologica. Supplementum
J A DunkelH Refsum

Abstract

Absorption and excretion of iodixanol 320 mg I/ml were investigated in rats after intragastric administration of 2.5 g I/kg b.w. Animals were observed for up to 96 hours after treatment, and blood, urine and feces taken at several time-points throughout the experiment. Concentrations of iodixanol in serum and urine were measured by means of reversed-phase high-performance liquid chromatography. Fecal concentrations of iodixanol, based on iodine measurements, were determined by X-ray fluorescence spectrometry. Serial radiographs were obtained and histopathological examination was performed on selected tissues. The results indicate that less than 1% of the intragastric dose of iodixanol is absorbed from the intestine into the blood stream. No adverse clinical signs were observed, and there were no treatment-related histomorphological findings.

References

Oct 1, 1970·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·C D Noonan, A R Margulis
Aug 1, 1983·Journal of Pediatric Surgery·M D CohenR Jansen
Jan 1, 1984·Pediatric Radiology·W H McAlister, M J Siegel
May 1, 1965·American Journal of Surgery·S W NELSONW J ROENIGK
Sep 1, 1962·Radiology·P A MORI, H A BARRETT
May 11, 1899·The Journal of Physiology·W M Bayliss, E H Starling

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