Absorption and Metabolic Behavior of Hesperidin (Rutinosylated Hesperetin) after Single Oral Administration to Sprague-Dawley Rats

Journal of Agricultural and Food Chemistry
Alexia M NectouxToshiro Matsui

Abstract

We investigated the absorption and metabolic behavior of hesperidin (hesperetin-7-O-rutinoside) in the blood system of Sprague-Dawley rats by liquid chromatography- and matrix-assisted laser desorption ionization mass spectrometries (LC-MS and MALDI-MS). After a single oral administration of hesperidin (10 mg/kg), which was expected to be absorbed in its degraded hesperetin form, we detected intact hesperidin in the portal vein blood (tmax, 2 h) for the first time. We successfully detected glucuronized hesperidin in the circulating bloodstream, while intact hesperidin had disappeared. Further MS analyses revealed that homoeriodictyol and eriodictyol conjugates were detected in both portal and circulating blood systems. This indicated that hesperidin and/or hesperetin are susceptible to methylation and demethylation during the intestinal membrane transport process. Sulfated and glucuronized metabolites were also detected in both blood systems. In conclusion, hesperidin can enter into the circulating bloodstream in its conjugated forms, together with the conjugated forms of hesperetin, homoeriodictyol, and/or eriodictyol.

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Citations

Dec 4, 2019·Clinical and Experimental Pharmacology & Physiology·Raushan KumarSyed Ibrahim Rizvi
Apr 8, 2020·Critical Reviews in Food Science and Nutrition·Abhisek KarnJinkai Zheng
Oct 22, 2020·Journal of Biomolecular Structure & Dynamics·Francisco Mosquera-YuquiEduardo A Moncayo-Palacio
Jan 15, 2021·Comprehensive Reviews in Food Science and Food Safety·Meiyan WangShiming Li
Apr 30, 2021·Frontiers in Pharmacology·Jianxiong WuQianfeng Gong
Aug 3, 2021·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Birgit Dusemund
Jul 11, 2020·Journal of Agricultural and Food Chemistry·Ye ZhangToshiro Matsui
Aug 28, 2021·Journal of Agricultural and Food Chemistry·Shang-Ta WangNan-Wei Su

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