Absorption, bioavailability, and metabolism of para-nonylphenol in the rat

Regulatory Toxicology and Pharmacology : RTP
Trevor GreenRonald L Joiner

Abstract

To better interpret the responses to para-nonylphenol (NP; CASRN84852-15-3) in in vivo toxicity studies, including estrogen-like activity, the bioavailability of 14C-radiolabelled NP has been determined in male and female CD rats following either single oral doses of 10 and 100 mg/kg, single i.v. doses of 10 mg/kg, or repeated daily oral doses of 10 mg/kg for up to 14 d. Up to 80% of an oral dose of NP was rapidly absorbed, the remainder being excreted unchanged in faeces. Excretion was largely complete within 24 h of dosing. Following absorption, NP was metabolised in the liver, with the majority of the metabolites excreted in bile, mainly as glucuronide conjugates. Unchanged NP was found only in bile and urine from female rats given a 100 mg/kg dose, indicating that metabolic saturation occurred. Following repeated dosing, steady state was reached within 7 d. There was no evidence of significant accumulation into tissue compartments nor of a significant change in clearance or the metabolite profiles in urine. These data suggest that the estrogen-like effects observed in toxicity studies with female rats at oral NP doses of approximately 50 mg/kg/d and greater are a result of the increased bioavailability of NP which occurs fo...Continue Reading

Citations

Jan 8, 2013·International Journal of Environmental Health Research·Yu JieXu Jie
Mar 10, 2009·Journal of Toxicology and Environmental Health. Part a·G HamelinR Tardif
Oct 14, 2006·The Journal of Reproduction and Development·Naoko KimuraKiyoshi Totsukawa
Sep 25, 2014·The Journal of Investigative Dermatology·Anika BruhsAgatha Schwarz
Aug 17, 2012·The Kaohsiung Journal of Medical Sciences·Jau-Ling SuenShau-Ku Huang
Feb 6, 2017·Marine Pollution Bulletin·Lucyna FalkowskaDominika Saniewska
Apr 7, 2005·Environmental Health Perspectives·Antonia M CalafatLarry L Needham
Mar 17, 2020·Environmental Science. Processes & Impacts·Wiesława RuczyńskaTomasz Nermer
Apr 27, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Xiaoyun YeAntonia M Calafat
Oct 8, 2020·Toxicology and Industrial Health·Haowei FuQian Xu

Related Concepts

4-tert-nonylphenol
Process of Absorption
High Pressure Liquid Chromatography Procedure
Dose-Response Relationship, Drug
Feces
Half-Life
Intravenous Injections
Liver
Total Body Clearance Rate
Phenols

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.