Absorption, distribution, metabolism and excretion pharmacogenomics of drugs of abuse

Pharmacogenomics
Markus R Meyer, Hans H Maurer

Abstract

Pharmacologic and toxic effects of xenobiotics, such as drugs of abuse, depend on the genotype and phenotype of an individual, and conversely on the isoenzymes involved in their metabolism and transport. The current knowledge of such isoenzymes of frequently abused therapeutics such as opioids (oxycodone, hydrocodone, methadone, fentanyl, buprenorphine, tramadol, heroin, morphine and codeine), anesthetics (γ-hydroxybutyric acid, propofol, ketamine and phencyclidine) and cognitive enhancers (methylphenidate and modafinil), and some important plant-derived hallucinogens (lysergide, salvinorin A, psilocybin and psilocin), as well as of nicotine in humans are summarized in this article. The isoenzymes (e.g., cytochrome P450, glucuronyltransferases, esterases and reductases) involved in the metabolism of drugs and some pharmacokinetic data are discussed. The relevance of such data is discussed for predicting possible interactions with other xenobiotics, understanding pharmacokinetic behavior and pharmacogenomic variations, assessing toxic risks, developing suitable toxicological analysis procedures, and finally for interpretating drug testing results.

References

Mar 1, 1992·Developmental and Comparative Immunology·T SasakiK Yonemasu
Oct 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P J SimonsR J Ruane
Sep 1, 1985·Journal of Neurochemistry·P VayerM Maitre
Feb 1, 1986·Oral Surgery, Oral Medicine, and Oral Pathology·S O IsaacsJ A Washington
Jan 1, 1974·International Anesthesiology Clinics·T Chang, A J Glazko
Aug 1, 1973·Journal of Medicinal Chemistry·H R Sullivan, S L Due
Jan 1, 1967·The Journal of Clinical Pharmacology and the Journal of New Drugs·J S Finch, T J DeKornfeld
May 1, 1982·Clinical Pharmacology and Therapeutics·C E CookS R Di Guiseppi
May 1, 1982·Clinical Pharmacology and Therapeutics·C E CookS R Di Guiseppi
Oct 1, 1982·Biopharmaceutics & Drug Disposition·A G HartzemaS Davis
Oct 1, 1981·Journal of Medicinal Chemistry·K S PatrickG R Breese
Nov 1, 1993·Clinical Pharmacology and Therapeutics·S V OttonE M Sellers
Jul 1, 1994·Journal of Psychoactive Drugs·L J Valdés
Oct 1, 1994·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J R SneydB Wright
Mar 1, 1993·Anesthesia and Analgesia·J H SilversteinK Zahl
May 15, 1993·BMJ : British Medical Journal·P A Gill
Oct 1, 1996·British Journal of Anaesthesia·K Hirota, D G Lambert
Jan 1, 1997·European Journal of Clinical Pharmacology·Q Y Yue, J Säwe
Apr 29, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·P BurnatB Do
Jul 21, 1998·JAMA : the Journal of the American Medical Association·E J Pérez-StableN L Benowitz
Aug 26, 1998·Neuropediatrics·A J BarkovichP Evrard
Apr 15, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·G K PochC J Anderson
Nov 26, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·S A ReuschelR L Foltz
Aug 5, 2000·Journal of Clinical Psychopharmacology·K KathiramalainathanE M Sellers
Aug 29, 2000·Naunyn-Schmiedeberg's Archives of Pharmacology·C GillenS Wnendt
Sep 6, 2000·Pharmacology·J D Hayes, R C Strange
Sep 9, 2000·Forensic Science International : Synergy·G Sticht, H Käferstein

❮ Previous
Next ❯

Citations

Jul 31, 2013·Forensic Science International : Synergy·Alan Wayne Jones, Patrick Harding
Oct 20, 2012·Lab Animal·Michael GuarnieriPatricia Zadnik
May 27, 2014·International Journal of Legal Medicine·Stefanie Iwersen-BergmannAxel Heinemann
Feb 11, 2016·Journal of Pain & Palliative Care Pharmacotherapy·Dermot P MaherAntonio Hernandez Conte
Sep 28, 2012·Expert Opinion on Drug Delivery·Michael Soyka
Dec 30, 2014·Expert Opinion on Drug Metabolism & Toxicology·Santosh KumarAnil Kumar
Sep 4, 2012·Clinics in Laboratory Medicine·Yash Pal Agrawal, Hanna Rennert
Dec 6, 2011·Forensic Science International : Synergy·Svetlana V KonstantinovaJørg Mørland
Jan 31, 2012·Journal of Veterinary Pharmacology and Therapeutics·A ZoncaP Cagnardi
Jun 15, 2011·Drug Testing and Analysis·Frank T Peters, Markus R Meyer
Jun 26, 2012·Immunological Reviews·Pierre-Antoine GourraudSergio E Baranzini
May 24, 2015·Forensic Science International : Synergy·Maria AnderssonOlof Beck
Jun 26, 2014·The Science of the Total Environment·Sara CastiglioniPaul Griffiths
Oct 25, 2016·Physiology & Behavior·Bruno Garcia MontagniniDaniela Cristina Ceccatto Gerardin
Mar 22, 2014·Journal of Pharmacy Practice·Gyula Bokor, Peter D Anderson
Oct 28, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Kuntheavy Ing Lorenzini, François Girardin
Feb 23, 2012·Human & Experimental Toxicology·M S M WaiD T Yew
Feb 5, 2021·European Journal of Drug Metabolism and Pharmacokinetics·Subrata Deb, Scott Arrighi
Jan 18, 2021·International Journal of Legal Medicine·S Iwersen-BergmannB Beer-Sandner
Nov 7, 2020·The Pharmacogenomics Journal·Christopher W MeadenCynthia D Santos
Jun 9, 2018·ACS Sensors·Ahmed H JalalShekhar Bhansali
Jun 30, 2018·ACS Chemical Neuroscience·Haden A GeigerR Nathan Daniels
Sep 4, 2021·Neurotoxicology·Silvia L CruzIker P Pérez-García
Dec 3, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·David Eapen-JohnJames L Kennedy

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
sedation

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.