PMID: 2510828Nov 17, 1989Paper

Absorption kinetics of beta-alanine as model compound in rat small intestine

Biochimica Et Biophysica Acta
M MerinoJ M Plá-Delfina

Abstract

Contradictory results have been reported on intestinal beta-alanine absorption, although a generalized view is that it could be a passive, nonmediated process. Since previous data from our laboratory suggested that some competition arises between intestinal absorption of the gamma-amino acidic drug baclofen and beta-alanine, a rat jejunum in situ study was undertaken in order to gain insight into the mechanism of beta-alanine absorption. Perfusion solutions with initial beta-alanine concentrations ranging from 0.3 to 56 mM were used. The beta-alanine absorption was clearly identified as a saturable process which obeys Michaelis-Menten equation kinetics, as assessed through two computer-assisted procedures based on differential and integrated forms of this equation. Parameter values found were: Vm = 3.88-4.72 mg.ml-1.h-1 (43.6-52.9 mM.h-1), and Km = 0.97-1.13 mg.ml-1 (10.9-12.7 mM). Statistical analysis does not account for the existence of significant parallel passive diffusion pathways (less than 0.2 h-1).

References

Jul 1, 1976·Proceedings of the Society for Experimental Biology and Medicine·R A Wapnir, F Lifshitz
Jan 1, 1976·Journal of Nutritional Science and Vitaminology·T HamaF Tsunemori
Dec 1, 1986·Journal of Pharmacokinetics and Biopharmaceutics·A Martín-VillodreA del Pozo
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Citations

Jan 1, 1996·Mycopathologia·A J Ramos, E Hernández
Oct 1, 1996·General Pharmacology·G N Balerio, M C Rubio
Oct 1, 1993·Antimicrobial Agents and Chemotherapy·M TanakaH Hakusui
Jul 1, 1994·Biopharmaceutics & Drug Disposition·A NácherM Merino
Apr 9, 2004·The Proceedings of the Nutrition Society·Dianne Ford
Aug 1, 1992·The Proceedings of the Nutrition Society·B Sandström
Jul 22, 2014·Journal of Animal Physiology and Animal Nutrition·E M GefellerU Lodemann
Sep 23, 2014·The American Journal of Clinical Nutrition·Graeme P YoungThomas G Brewer
Oct 1, 1990·The Journal of Pharmacy and Pharmacology·F Torres-MolinaJ M Plá-Delfina

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