Absorption kinetics of oral sotalol combined with cisapride and sublingual sotalol in healthy subjects

British Journal of Clinical Pharmacology
V H DeneerJ R Brouwers

Abstract

To study the absorption kinetics of sotalol following administration of different formulations. A formulation which results in fast absorption might be useful in the episodic treatment of paroxysmal supraventricular tachycardia (SVT), atrial fibrillation (Afib) or atrial flutter (Afl). In an open randomized crossover study seven healthy male volunteers were given an intravenous infusion of 20 mg sotalol, for assessing the absolute bioavailability, an oral solution containing 80 mg sotalol, an oral solution containing both 80 mg sotalol and 20 mg cisapride and an 80 mg sotalol tablet, which was taken sublingually. The addition of cisapride decreased the time at which maximum serum concentrations were reached (tmax) from 2.79 (1.85-4.34) h to 1.16 (0.68-2.30) h (P=0.009) [95% CI: -2.59, -0.55] and increased the absorption rate constant (ka) from 0.49 (0.31-0.69) h(-1) to 1.26 (0.52-5.61) h(-1) (P=0.017). The absolute bioavailability of sotalol was reduced by cisapride from 1.00+/-0.15 to 0.70+/-0.26 (P=0.006), while maximum serum concentrations of both oral solutions were not significantly different. Compared with the sublingually administered tablet with a median tmax of 2.12 (0.89-3.28) h, the sotalol/cisapride oral solution ga...Continue Reading

References

Mar 22, 1976·European Journal of Clinical Pharmacology·H C BrownR G Shanks
Jul 1, 1976·Acta Pharmacologica Et Toxicologica·M AnttilaH Sundquist
Jan 1, 1992·European Journal of Clinical Pharmacology·D J RowbothamW S Nimmo
Aug 1, 1987·Alimentary Pharmacology & Therapeutics·B KrevskyR S Fisher
Oct 1, 1986·European Journal of Drug Metabolism and Pharmacokinetics·W KirchE E Ohnhaus
Dec 1, 1987·Digestive Diseases and Sciences·R J GilbertS Lipman
Oct 1, 1985·Journal of Pharmaceutical Sciences·J H Proost
Jan 1, 1984·British Journal of Anaesthesia·A G De BoerD D Breimer
Jan 1, 1984·European Journal of Clinical Pharmacology·R BaeyensM Verlinden
Dec 1, 1984·The American Journal of Medicine·A SquireP Schweitzer
Mar 1, 1980·The American Journal of Cardiology·B MargolisB Lown
Jul 1, 1980·British Journal of Clinical Pharmacology·J A HenryP Turner
Nov 1, 1996·British Journal of Clinical Pharmacology·M KimuraM Nakashima

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