PMID: 488572Aug 1, 1979Paper

Absorption kinetics of subcutaneously injected insulin. Evidence for degradation at the injection site

Diabetologia
M BergerA E Renold

Abstract

The absorption of subcutaneously injected insulin was examined by injecting semisynthetic [3H] insulin in anaesthetized pigs and subsequently analysing the tissue excised from the injection site. Contrary to previously accepted views, a significant proportion of insulin was degraded at the injection site. The disappearance of intact [3H] insulin from the injection site followed a monoexponential function with a half-time of 59 min.

References

Jan 28, 1978·British Medical Journal·J C PickupK G Alberti
Jan 12, 1978·The New England Journal of Medicine·V A Koivisto, P Felig
Nov 15, 1976·The Biochemical Journal·P A HalbanR E Offord
Jan 1, 1962·The American Journal of the Medical Sciences·M C BALODIMOS, R H WILLIAMS
Apr 1, 1964·The Journal of Pediatrics·J J NORAJ R CAMERON

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Citations

Jul 1, 1982·Indian Journal of Pediatrics·S C Kalhan
Jan 27, 2004·Advanced Drug Delivery Reviews·G M SteilK Rebrin
Jun 6, 2000·Computer Methods and Programs in Biomedicine·T ArlethM M Benedetti
Jul 17, 1986·The New England Journal of Medicine·D S Schade, W C Duckworth
Jan 5, 2005·Diabetes Technology & Therapeutics·Lutz Heinemann, James H Anderson
May 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·A VaagH Beck-Nielsen
Jun 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·J E HenriksenH Beck-Nielsen
Jul 17, 1982·British Medical Journal·T LauritzenC Binder
Aug 12, 1989·BMJ : British Medical Journal·S JørgensenJ Markussen
Mar 1, 1981·The Journal of Clinical Investigation·J PhilippeA E Renold
May 24, 2012·The AAPS Journal·Wolfgang F RichterMarilyn E Morris
Sep 1, 1993·Biomedizinische Technik. Biomedical Engineering·Z TrajanoskiF Skraba
Jun 13, 2013·Computer Methods and Programs in Biomedicine·Zimei WuStephen Chang
Aug 31, 2004·Metabolism: Clinical and Experimental·Maria Pia FrancescatoLuigi Cattin
Apr 1, 1981·Metabolism: Clinical and Experimental·V A KoivistoP Felig
Jan 18, 2005·IEEE Transactions on Bio-medical Engineering·Malgorzata E WilinskaRoman Hovorka
Nov 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·S M Furler, E W Kraegen
May 1, 1985·Diabetic Medicine : a Journal of the British Diabetic Association·R J HeineE A van der Veen
Sep 1, 1985·Diabetic Medicine : a Journal of the British Diabetic Association·P HildebrandtC Kühl
Jul 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·P Hildebrandt, K Birch
Apr 25, 2006·Metabolism: Clinical and Experimental·Samuel J FriedbergRobert I Gregerman
Jun 28, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Tue SøeborgMorten Colding-Jørgensen
Jul 27, 2005·Diabetes Care·Unn-Britt JohanssonPer-Eric Lins
Mar 1, 1984·Archives of Biochemistry and Biophysics·R A McKenzie, G A Burghen
Jun 9, 2018·The Journal of Biological Chemistry·Nischay K RegeMichael A Weiss
Aug 8, 2014·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Wolfgang F Richter, Björn Jacobsen
Aug 18, 2018·Journal of Diabetes Research·A K J GradelH H F Refsgaard
Dec 11, 2019·Antibodies·Veena A Thomas, Joseph P Balthasar
Jun 6, 2020·Journal of Pharmacokinetics and Pharmacodynamics·Shihao Hu, David Z D'Argenio
Jul 1, 1982·Acta Pharmacologica Et Toxicologica·T DeckertM Smith
Nov 1, 1987·The American Journal of Physiology·C CobelliI Jensen

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