Absorption mechanism of whey-protein-delivered curcumin using Caco-2 cell monolayers

Food Chemistry
Ming LiYing Ma

Abstract

Curcumin (CCM) is a bioactive polyphenolic compound that suffers a low bioavailability because of its low water solubility. In this work β-lactoglobulin (β-Lg) and nanoemulsion were used as carriers to deliver curcumin. The pH stability of β-Lg-CCM was investigated. The digestion of β-Lg-CCM and the nanoemulsion was studied using an in vitro gastrointestinal model. The effect of different carriers on the permeability of curcumin was assessed using the Caco-2 cell monolayer model. The results revealed that the water solubility and the pH stability of curcumin significantly increased by binding with β-Lg. In SDS-PAGE experiments the β-Lg-CCM complex and nanoemulsion were found to be resistant to pepsin digestion but sensitive to trypsin. In the permeability experiment it was shown that the digested nanoemulsion and β-Lg-CCM improved significantly the permeation rate of curcumin.

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Citations

Aug 23, 2019·Journal of Food Science·Francesca CuomoFrancesco Lopez
Sep 16, 2017·Journal of Food and Drug Analysis·Bing HuXiaoxiong Zeng
Oct 1, 2020·Antioxidants·Josipa GrgićAna Bucić-Kojić
Jun 28, 2017·Biomicrofluidics·Zhongyu LiJianhua Qin
Jun 15, 2019·BMC Complementary and Alternative Medicine·Ashlesha P PanditVinita C Patole
Jan 16, 2021·Journal of Colloid and Interface Science·Naisarg PujaraAmirali Popat
Feb 23, 2021·ACS Biomaterials Science & Engineering·Vanessa Jane BanunAmirali Popat
Oct 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bingyan YangYu Zhang
Jun 26, 2021·Food Chemistry·Farhad GaravandSeid Mahdi Jafari

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