Absorption-mode: the next generation of Fourier transform mass spectra

Analytical Chemistry
Yulin QiPeter B O'connor

Abstract

The Fourier transform spectrum can be presented in the absorption-mode (commonly used in FT-NMR), magnitude-mode (FT-ICR), and power-mode (engineering applications). As is routinely used in FT-NMR, it is well-known that the absorption-mode display gives a much narrower peak shape which greatly improves the spectrum; recently, the successful solution of the phase equation allowed broadband phase correction which makes it possible to apply the absorption-mode routinely in FT-ICR. With the empirical evidence provided herein, it has been confirmed that in addition to the improvement on resolving power, compared to the conventional magnitude-mode, the new absorption-mode improves the signal-to-noise ratio (S/N) of a spectrum by 1.4-fold and can improve the mass accuracy up to 2-fold with no extra cost in instrumentation. Therefore, it is worthwhile to apply and promote absorption-mode in routine FT-ICR experiments.

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Citations

Apr 10, 2013·Journal of the American Society for Mass Spectrometry·Yulin QiPeter B O'Connor
May 3, 2014·Journal of the American Society for Mass Spectrometry·Tagir AushevYury O Tsybin
Jul 12, 2014·Annual Review of Analytical Chemistry·Zhaorui ZhangLjiljana Paša-Tolić
Aug 14, 2013·Rapid Communications in Mass Spectrometry : RCM·David P A KilgourPeter B O'Connor
Aug 1, 2012·Rapid Communications in Mass Spectrometry : RCM·Yulin QiPeter B O'Connor
Mar 19, 2016·Analytical Chemistry·Maria A van AgthovenPeter B O'Connor
Jul 18, 2015·Journal of the American Society for Mass Spectrometry·Maria A van AgthovenPeter B O'Connor
Jun 6, 2015·Rapid Communications in Mass Spectrometry : RCM·David P A Kilgour, Steven L Van Orden
Jun 6, 2015·Rapid Communications in Mass Spectrometry : RCM·David P A KilgourYury O Tsybin
Dec 17, 2016·Analytical Chemistry·Dmitry GrinfeldAlexander Makarov
Feb 2, 2018·Journal of the American Society for Mass Spectrometry·Mowei ZhouLjiljana Paša-Tolić
Jan 10, 2014·Mass Spectrometry Reviews·Yulin Qi, Peter B O'Connor
Dec 9, 2020·Mass Spectrometry Reviews·Juan D ChavezJames E Bruce
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Jan 6, 2018·Analytical Chemistry·Donald F SmithChristopher L Hendrickson

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