PMID: 22567976May 10, 2012Paper

Absorption of arginine-vasopressin and arginine-vasotocin in small intestine of the frog Rana temporaria

Zhurnal evoliutsionnoĭ biokhimii i fiziologii
N P Prutskova, E V Seliverstova

Abstract

Experiments in vitro demonstrated a partial absorption of arginine-vasopressin (AVP) in the frog small intestine. Dynamics and efficiency of the nonapeptide absorption are studied with use of hydroosmotic method of recording of the osmotic permeability of the frog urinary bladder epithelium and immunoenzyme analysis. In the process of absorption there were preserved intactness of the hormone cyclic structure and its physiological activity, like in the case of the arginine-vasotocin (AVT) absorption. The AVP absorption increased at its administration into the gut with inhibitor of proteases. By methods of immunoelectron and immunofluorescent microscopy with use of polyclonal antibody to AVP, location of the label to the hormone was shown in the enterocyte cytoplasm. Thus, there was obtained a morphological evidence for the AVP absorption and transepithelial transfer in the frog small intestine. These data enlarge the concept of the poorly studied properties of the absorbing epithelium of the vertebrate intestine with respect to absorption of intact molecules of polypeptides.

References

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Oct 24, 2002·Acta Physiologica Scandinavica·S WheelerJ D Morrison
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Apr 20, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·E V SeliverstovaYu V Natochin

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Citations

Jul 26, 2012·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·E V Seliverstova, N P Prutskova

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