Absorption of Codonopsis pilosula Saponins by Coexisting Polysaccharides Alleviates Gut Microbial Dysbiosis with Dextran Sulfate Sodium-Induced Colitis in Model Mice

BioMed Research International
Yaping JingChunjiang Zhang

Abstract

Inflammatory Bowel Disease (IBD) is an autoimmune disease, and the gut microbiota has become a new therapeutic target. Herbal medicine (HM) has shown good efficacy in the clinical treatment of IBD; however, the synergistic actions of the dominant chemicals in HM decoctions are unclear. In this study, we explored whether the complicated interconnections between HM and the gut microbiota could allow crosstalk between HM ingredients. Saponins and polysaccharides, i.e., the dominant chemicals in the Codonopsis pilosula Nannf (CPN) decoction, were investigated in a dextran sulfate sodium- (DSS-) induced mouse model. Bacterial 16S rRNA sequencing analyzed the change of gut microbiota structure and diversity. Gas chromatography (GC) determined the content of short-chain fatty acids (SCFAs) in feces. ELISA detected the expression of proinflammatory and anti-inflammatory cytokines associated with TH17/Treg balance. UPLC-QTOF-MS technology combined with PKsolver software analyzed the absorption of the highest exposure for monomeric compounds of CPN saponins in serum. The results indicated that CPN polysaccharides showed prebiotic-like effects in mice with DSS-induced colitis by simultaneously stimulating the growth of three important pro...Continue Reading

References

Sep 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·J L Rombeau, S A Kripke
Dec 9, 1998·Clinical and Experimental Immunology·L A DielemanE P Van Rees
Feb 8, 2002·Applied Microbiology and Biotechnology·M GupteB N Ganguli
Jun 9, 2004·Journal of Clinical Microbiology·Ulrich R M BohrPeter Malfertheiner
Sep 25, 2004·International Journal of Systematic and Evolutionary Microbiology·Muriel DerrienWillem M de Vos
Oct 16, 2004·Digestive Diseases and Sciences·Christelle BassetStuart Bloom
May 24, 2005·Apoptosis : an International Journal on Programmed Cell Death·F HabensG Packham
Oct 6, 2005·Applied and Environmental Microbiology·Maddalena RossiDiego Matteuzzi
Oct 21, 2005·The New England Journal of Medicine·Turk Rhen, John A Cidlowski
Oct 28, 2006·Gastroenterology·Alan C Moss, Richard J Farrell
Feb 2, 2008·Nature Reviews. Drug Discovery·Wei JiaJeremy K Nicholson
Jul 22, 2008·International Journal of Biological Macromolecules·Sun Yongxu, Liu Jicheng
Sep 17, 2008·Nature Reviews. Microbiology·Ruth E LeyJeffrey I Gordon
Dec 18, 2008·The American Journal of Gastroenterology·Kelvin T ThiaSuk-Kyun Yang
Mar 3, 2009·Inflammatory Bowel Diseases·Clara Abraham, Judy Cho
May 26, 2009·Arquivos De Gastroenterologia·Carlos Roberto VictoriaHélio Rubens de Carvalho Nunes
Jul 8, 2009·Journal of Agricultural and Food Chemistry·María V SelmaFrancisco A Tomás-Barberán
May 1, 2002·FEMS Microbiology Ecology·Julien LoubinouxAlain E Faou
Feb 24, 2010·Computer Methods and Programs in Biomedicine·Yong ZhangShaofei Xie
May 19, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Tatiana AkimovaWayne W Hancock
May 10, 2011·Drug Design, Development and Therapy·John K TriantafillidisFilippos Georgopoulos
Jun 17, 2011·Nature·Bernard KhorRamnik J Xavier
Jun 17, 2011·Nature·Andrew L KauJeffrey I Gordon
Feb 22, 2012·Molecular Nutrition & Food Research·Gregory HostetlerAndrea I Doseff
May 2, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Si-Yuan PanKam-Ming Ko
Jun 12, 2013·Nature Reviews. Microbiology·Abdessamad El KaoutariBernard Henrissat
Mar 19, 2014·Gut Microbes·Julie MirpuriFelix Yarovinsky
Jun 21, 2014·Immunity·Curtis HuttenhowerRamnik J Xavier

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Citations

Nov 17, 2019·Paediatric Anaesthesia·Christa MorrisonTim Liversedge
Mar 9, 2019·Applied Microbiology and Biotechnology·Ishu Khangwal, Pratyoosh Shukla
Sep 6, 2019·Helicobacter·Armelle Ménard, Annemieke Smet
Nov 16, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yan-Ni LiangZhi-Shu Tang
Jan 29, 2020·International Journal of Biological Macromolecules·Zhifei FuErwei Liu
Oct 29, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yao LiXiaohui Zheng
Feb 10, 2021·Critical Reviews in Food Science and Nutrition·Yi WangWing-Fu Lai
Apr 17, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Jiankuan LiJianping Gao
Apr 9, 2021·The American Journal of Chinese Medicine·Hui ZhaoHaibo Xu

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
PCR
PCA

Software Mentioned

UniFrac
PKsolver
LEfSe
Origin
R

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