PMID: 9434275Jan 22, 1998Paper

Absorption of D-glucose in the rat studied using in situ intestinal perfusion: a permeability-index approach

Pharmaceutical Research
Y WangF L Tse

Abstract

A permeability-index approach was developed and used to study the transport of D-glucose in the jejunum and ileum of rats. The effective permeability coefficient (Pe) of [3H]D-glucose and [14C]antipyrine (an internal standard) in jejunum and ileum of four rats was determined using an in situ rat intestinal perfusion technique. The permeability ratio of the test compound (D-glucose) to the internal standard was defined as the permeability-index (P(i)), which was mathematically independent of the length and surface area of the intestinal segment perfused. Using this approach, the transport of [3H]D-glucose in jejunum and ileum of eight animals was investigated at concentrations ranging from 1 to 300 mM. The tissue/perfusate distribution of [3H]D-glucose and [14C]antipyrine at steady state was also determined. The variability (%CV) in P(i) of D-glucose was only approximately 5%, compared with 23-36% in Pe values of D-glucose or antipyrine alone. The permeability and tissue distribution of [14C]antipyrine were unaffected by the presence of D-glucose. In contrast, the permeability and tissue distribution of [3H]D-glucose were concentration-dependent in both jejunum and ileum. The transport of D-glucose was studied assuming that the ...Continue Reading

Citations

Apr 17, 1999·Biopharmaceutics & Drug Disposition·Y WangF L Tse
Oct 7, 2006·Current Opinion in Gastroenterology·D F NuttingC M Mansbach
Mar 13, 2010·Biotechnology and Applied Biochemistry·Aldo Leal-Egaña, Thomas Scheibel
Dec 10, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·D F NuttingC M Mansbach
Jul 20, 2005·Pharmaceutical Research·Li ZhangZhong Zuo
Jul 10, 2019·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·I R DubbelboerH Lennernäs

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