Absorption of folic acid from a softgel capsule compared to a standard tablet

Journal of the Academy of Nutrition and Dietetics
Kevin C MakiMary R Dicklin

Abstract

Consumption of 400 μg folic acid per day from fortified foods and/or supplements, plus food folate from a varied diet is recommended for women of childbearing potential to reduce the risk for neural tube defects during fetal development. This randomized crossover study was designed to evaluate the bioavailability of folic acid from a multivitamin softgel capsule vs a folic acid tablet in 16 premenopausal women (18 to 45 years of age). Participants were randomly assigned to receive a single dose of ∼1,000 μg folic acid in two tablets or ∼1,000 μg folic acid in a multivitamin softgel capsule, and then crossed over to receive the other study product ∼1 week later. Products were administered with a low-folate breakfast. Blood samples were collected predose (0 hour) and 1, 2, 3, 4, 6, and 8 hours post-dose for serum folate analysis. Repeated measures analysis of variance was used to compare responses between treatments. Data from the two sequence groups (n=8 per sequence) were pooled. Mean serum folate total and net incremental areas under the curve (AUC(0-8 hours)) were not significantly different between tablets and softgel capsule (AUC(0-8 hours) 214.9±11.2 hours×ng/mL [487±25.4 hours×nmol/L] and 191.6±13.3 hours×ng/mL [434.2±30....Continue Reading

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Citations

Oct 25, 2016·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Huijing Wang, Weiliang Chen
May 23, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Lingtak-Neander Chan, Leigh Ann Mike
Jul 17, 2018·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Jessica BayesJanet Schloss
Nov 15, 2013·Advances in Nutrition·Kevin B Comerford

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