Absorption of nitro-polycyclic aromatic hydrocarbons by biomembrane models: effect of the medium lipophilicity

Chemosphere
Francesco CastelliV Librando

Abstract

To demonstrate the relationship between the structure of nitro-polycyclic aromatic hydrocarbons and their effect on biomembranes, we have investigated the influence of three structurally different nitro-polycyclic aromatic hydrocarbons, 2-nitrofluorene, 2,7-dinitrofluorene and 3-nitrofluoranthene, on the thermotropic behavior of dimyristoylphosphatidylcholine multilamellar vesicles, used as biomembrane models, by means of differential scanning calorimetry. The obtained results indicate that the studied nitro-polycyclic aromatic hydrocarbons affected the thermotropic behavior of multilamellar vesicles to various extents, modifying the pretransition and the main phase transition peaks and shifting them to lower temperatures. The effect of the aqueous and lipophilic medium on the absorption process of these compounds by the biomembrane models has been also investigated revealing that the process is hindered by the aqueous medium but strongly allowed by the lipophilic medium.

References

Mar 1, 1991·Chemistry and Physics of Lipids·B Tenchov
Jan 1, 1990·Drug Metabolism Reviews·P P Fu
Sep 1, 1988·Mutation Research·B Beije, L Möller
Sep 1, 1982·Journal of Toxicology and Environmental Health·T C MarshallA L Brooks
Aug 24, 2000·Chemical Research in Toxicology·V Purohit, A K Basu
Jul 9, 2002·Environmental Science & Technology·Francesco CastelliMaria Grazia Sarpietro
Jun 1, 2003·Environmental Toxicology and Pharmacology·Vito LibrandoFrancesco Castelli
Apr 1, 2004·Environmental Toxicology and Pharmacology·Nelli FarkasJoseph Belagyi

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Citations

Apr 3, 2012·Journal of Zhejiang University. Science. B·Bo XieQing Yang
May 2, 2015·Environmental Toxicology and Pharmacology·Vito LibrandoMaria Grazia Sarpietro
Jun 5, 2013·Journal of Molecular Graphics & Modelling·Vito Librando, Matteo Pappalardo
Nov 23, 2018·Biochimica Et Biophysica Acta. Biomembranes·N A KasianL N Lisetski

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