PMID: 9449161Jan 1, 1997Paper

Absorption of topical tacrolimus (FK506) in vitro through human skin: comparison with cyclosporin A

Skin Pharmacology : the Official Journal of the Skin Pharmacology Society
A I LauermaH I Maibach

Abstract

Cyclosporin A (CsA) is efficacious in many dermatoses as an oral but not as a topical form, while tacrolimus (FK506) has been shown to be effective in both forms. As inadequate skin absorption has been proposed as the reason for inefficacy of topical CsA, factors contributing to percutaneous absorption of FK506 and CsA were studied. Partitioning of FK506 and CsA between octanol and water, stratum corneum and water, and stratum corneum and isopropyl myristate was determined. Absorption of FK506 and CsA through dermatomed human cadaver skin was determined with in vitro flow-through cells. In partitioning experiments, CsA was more lipophilic than FK506. Both drugs were seen in comparable amounts in skin layers, but FK506 permeated the skin to a greater extent than CsA.

Citations

Jan 14, 2005·Journal of Cutaneous Medicine and Surgery·Daniel N Sauder
Nov 21, 2002·Current Gastroenterology Reports·Charles N Bernstein
Jul 8, 1999·European Journal of Pharmacology·S KochiY Sawada
Jul 6, 2000·Immunopharmacology·T AssmannT Ruzicka
Aug 14, 2002·Veterinary Dermatology·Rosanna Marsella, Constance F Nicklin
Nov 30, 2000·International Journal of Dermatology·E J ZabawskiC J Cockerell
Apr 21, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Armorél D Van EykDavid Meyer
May 15, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Eriko FujitaHidetaka Kamimura
May 15, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Eriko FujitaHidetaka Kamimura
Dec 24, 2010·Journal of Gastroenterology and Hepatology·Ian Craig Lawrance
Nov 13, 2004·Drugs·Thomas Christian RoosHarald Brost
Apr 30, 2002·American Journal of Clinical Dermatology·Jennifer Cather, Alan Menter
May 18, 2011·World Journal of Gastrointestinal Pharmacology and Therapeutics·Ian Craig Lawrance
Dec 17, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sunny KumarSamir Mitragotri
Jan 16, 2016·Therapeutic Delivery·Renquan RuanLongping Wen
Nov 28, 2012·The Veterinary Clinics of North America. Small Animal Practice·Brian S Palmeiro
Dec 21, 2005·The Veterinary Clinics of North America. Small Animal Practice·Stephanie R Bruner
Feb 5, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Thomas ReinhardRainer Sundmacher
Mar 20, 2004·Veterinary Dermatology·Eric GuaguèreThierry Olivry
Sep 3, 2008·Alimentary Pharmacology & Therapeutics·I C Lawrance, T-S Copeland
Apr 20, 2005·Dermatologic Clinics·Daniel N Sauder, Mona Z Mofid
Feb 18, 2003·The British Journal of Dermatology·T KanekuraT Kanzaki
Mar 14, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ian C LawranceSusan Connor
Jun 6, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·A K GuptaM Chow
Sep 19, 2018·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Bin-Wu LinZi-Man Chen
Jan 5, 2002·Seminars in Cutaneous Medicine and Surgery·I BekerskyI Lawrence
Jul 1, 2007·Expert Review of Clinical Immunology·David A Wrone, Daniel N Sauder
Jul 3, 2019·International Journal of Molecular Sciences·Wei ZhangSatohiro Masuda
May 11, 2001·The Annals of Pharmacotherapy·P A Skaehill
Jan 13, 2001·Dermatologic Clinics·J C CatherA Menter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Dermatology : International Journal for Clinical and Investigative Dermatology
Tarun NarangDavinder Parsad
Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Rafael LuboshitzkyAvraham Ishay
The British Journal of Dermatology
E C BentonR S Barnetson
International Journal of Dermatology
M Lane-Brown
© 2021 Meta ULC. All rights reserved