Absorption of zinc and retention of calcium: dose-dependent inhibition by phytate

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
K FredlundAnn-Sofie Sandberg

Abstract

The dose-dependent inhibitory effect of sodium phytate (myo-inositol-hexaphosphate) on absorption of zinc and retention of calcium was studied in man. No systematic study of this dose-response effect has been reported to this time. Forty subjects were served meals containing white wheat rolls without/with additions of phytate. Ten subjects were given test meals containing one or two of the studied levels of phytate and in addition all subjects were served meals to which no phytate was added. The zinc content was 3.1 mg (47 micromol) and the calcium content 266 mg (6.6 mmol). The rolls were labelled extrinsically with radioisotopes, 65Zn and 47Ca, and whole-body retention of both minerals was measured. Totally 105 meals were served, 36 meals in which no phytate was added and 9-10 meals on each level of phytate. The zinc absorption in meals to which either 0, 25, 50, 75, 100, 140, 175 or 250 mg of phytate-P (0, 134, 269, 403, 538, 753, 941 or 1344 micromol phytate) had been added was 22%, 16%, 14%, 11%, 7%, 7%, 7% and 6%, respectively (mean values). The addition of 50 mg phytate-P or more significantly decreased zinc absorption (p=0.01) as compared to absorption from the test meals with no added phytate. The calcium retention at ...Continue Reading

References

Jan 1, 1978·International Journal of Nuclear Medicine and Biology·B ArvidssonB Sandström
Jun 1, 1992·Proceedings of the Society for Experimental Biology and Medicine·C M Weaver
Nov 1, 1965·Proceedings of the Society for Experimental Biology and Medicine·P VohraF H Kratzer
Feb 1, 1995·International Journal of Food Sciences and Nutrition·A Wise
Feb 1, 1995·The Journal of Clinical Endocrinology and Metabolism·M J Barger-LuxH F DeLuca
Apr 3, 1998·Health Physics·M ThiemeR Gödde
Jun 16, 2000·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·M IsakssonL Rossander-Hulthén
Aug 29, 1958·Science·W P NORRISA M BRUES
Feb 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·V T MADDAIAHB L REID
Dec 4, 2003·European Journal of Clinical Nutrition·K FredlundA-S Sandberg
Jun 2, 1942·The Journal of Physiology·R A McCance, E M Widdowson
Nov 30, 1942·The Journal of Physiology·R A McCance, E M Widdowson

❮ Previous
Next ❯

Citations

Aug 2, 2002·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Kerstin FredlunAnn-Sofie Sandberg
Mar 10, 2009·The British Journal of Nutrition·Jihye KimHyojee Joung
May 24, 2012·The British Journal of Nutrition·Leland V MillerK Michael Hambidge
Aug 21, 2013·Critical Reviews in Food Science and Nutrition·Nicola M LoweVictoria Hall-Moran
Nov 19, 2013·Aquatic Biosystems·Emmanuelle Apper-BossardFrédérique Respondek
Aug 1, 2010·Nutrients·Mark Messina, Virginia Messina
Aug 16, 2013·Nutrients·Karen H C LimEwa A Szymlek-Gay
Mar 27, 2009·The Journal of Nutrition·Tom D ThacherSteven A Abrams
Apr 18, 2014·Nutrition Reviews·Silvia Bel-SerratUNKNOWN EURRECA Network
Apr 3, 2014·Nutrition Reviews·Michael R La FranoBetty J Burri
Mar 5, 2013·Journal of Bioscience and Bioengineering·Yuzhi MiaoYi Cao
Nov 22, 2008·Journal of Food Science·S CharoenkiatkulC M Weaver
Jun 15, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Vikas KumarKlaus Becker
Dec 19, 2015·Journal of the Science of Food and Agriculture·Anne Vf Nielsen, Anne S Meyer
Mar 10, 2009·The Journal of Nutritional Biochemistry·Lisa M GaetkeMary A Stuart
Nov 26, 2016·Journal of the Science of Food and Agriculture·Daniela ErbaMaria C Casiraghi
Jul 21, 2016·Environmental Geochemistry and Health·Edward J M JoyMichael J Watts
Jan 6, 2018·Nutrients·Gianluca Rizzo, Luciana Baroni
Dec 3, 2015·Food & Nutrition Research·Claudia E LazarteYvonne Granfeldt
Dec 22, 2006·The Journal of Nutrition·Leland V MillerK Michael Hambidge
Apr 15, 2011·The American Journal of Clinical Nutrition·Nafissatou Ba LoKenneth H Brown
Mar 12, 2020·Physiology and Molecular Biology of Plants : an International Journal of Functional Plant Biology·J Lydia PramithaR Ravikesavan
Jan 1, 2017·Plant and Soil·Edward J M JoyMartin R Broadley
May 29, 2009·Food and Nutrition Bulletin·Sonja Y Hess, Kenneth H Brown
Aug 4, 2007·The Journal of Bone and Joint Surgery. British Volume·C Lee, S Lashari
Aug 26, 2014·Radiation Protection Dosimetry·Jenny Nilsson, Mats Isaksson
Nov 17, 2020·Critical Reviews in Food Science and Nutrition·Yianna Y ZhangSaid Ajlouni
Mar 3, 2021·Food Research International·Inger-Cecilia Mayer LabbaAnn-Sofie Sandberg
Nov 8, 2008·Journal of Agricultural and Food Chemistry·B Dave OomahParthiba Balasubramanian
Nov 16, 2012·Journal of Agricultural and Food Chemistry·Juan Mario Sanz-PenellaMonika Haros

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
M IsakssonLena Rossander-Hulthén
The British Journal of Nutrition
Ann-Sofie Sandberg
© 2022 Meta ULC. All rights reserved