Absorption phase cyclosporine (C(2h)) monitoring in the first weeks after pediatric renal transplantation

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Udo VesterP F Hoyer

Abstract

Cyclosporine (CsA) monitoring using abbreviated area under the curve or 2-h blood concentration (C(2h))has been shown to predict total drug exposure in adult renal transplantation. However, pediatric experience is limited. Since 1998, we have monitored C(2h) in 45 children (age 10.6+4.7 years) during the first 6 weeks after transplantation. In 22 a 4-h CsA profile (AUC(0-4h)) was available and C(2h) in the remaining 23 patients. In addition CsA profiles from 24 children transplanted before 1998 were used to calculate the correlation between single time points and AUC(0-4h). The best correlation between AUC(0-4h) and a single time point was seen with C(2h) (r(2)=0.89). Coh did not predict AUC(0-4h) reliably (r(2)=0.27). C(2h) showed the lowest prediction error (10.0+9.6%).No dependency on age could be detected. In the first 3 months following transplantation, rejection was ob-served in 9 of 45 patients (20%). Glomerular filtration rate remained stable within the first 5 years after trans-plantation. In conclusion, in the early phase after renal transplantation, C(2h) can be used to predict drug exposure within the whole pediatric age group and should be evaluated in prospective trials.

References

May 6, 1999·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·L Dello StrologoG Rizzoni
May 6, 1999·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·G FillerJ H Ehrich
Dec 22, 1999·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·H U Meier-KriescheR J Portman
Mar 29, 2001·Journal of the American Society of Nephrology : JASN·Kamran MahalatiJoseph Lawen
Oct 2, 2001·Transplantation·UNKNOWN Canadian Neoral Renal Transplantation Study Group
May 23, 2002·Transplantation·Björn NashanEric Thervet
May 23, 2002·Transplantation·Gary LevyUNKNOWN Consensus on Neoral C(2): Expert Review in Transplantation (CONCERT) Group
Jul 9, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·UNKNOWN Internation Neoral Renal Transplantation Study Group
Jul 18, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Elias David-NetoLuiz E Ianhez
Sep 18, 2002·Pediatric Transplantation·Elias David-NetoLuiz Estevam Ianhez
Oct 8, 2003·Transplantation Proceedings·L T WeberUNKNOWN German Study Group Pediatric Renal Transplantation

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Citations

Apr 26, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Lutz T Weber

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