PMID: 8592867Nov 1, 1995Paper

Absorption, tissue distribution, metabolism and excretion of ormetoprim and sulphadimethoxine in Atlantic salmon (Salmo salar) after intravenous and oral administration of Romet

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
O B SamuelsenV Wennevik

Abstract

1. Uptake, bioavailability, tissue disposition and elimination of sulphadimethoxine (SDM) and ormetoprim (OMP) were examined in Atlantic salmon (Salmo salar) following intravenous and oral administration of Romet at a dose of 5 mg OMP and 25 mg SDM kg-1 fish. 2. Plasma clearance was rapid for both drugs following a single i.v. dose, characterized by t1/2 alpha = 0.48 and 0.54h, t1/2 beta = 9.9 and 25.6h for SDM and OMP respectively with a volume of distribution (Vss) = 0.389 and 2.478 l kg-1. 3. Following oral administration, peak plasma concentrations of 1.13 and 9.99 micrograms ml-1 were achieved after 17.6 and 20.3h for OMP and SDM respectively. Bioavailabilities were 85% for OMP and 39% for SDM. 4. Oral administration revealed the highest concentration of OMP in kidney and liver whereas the highest concentrations of SDM were found in muscle and bile. 5. High concentrations of N4-acetylated SDM were found in the bile indicating significant metabolism of SDM.

References

Dec 1, 1990·International Journal for Parasitology·A Canals, L C Gasbarre
Dec 1, 1990·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·C M MichelJ M O'Connor
Feb 1, 1990·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B F DroyK M Kleinow
Jan 1, 1989·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·B F DroyK M Kleinow
Mar 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M G BarronM O James
Sep 1, 1994·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M G Barron, M O James
Oct 14, 1994·Journal of Chromatography. B, Biomedical Applications·O B Samuelsen

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