Abstinence-orientated buprenorphine replacement therapy for young adults in out-patient counselling

Drug and Alcohol Review
Hege KornørRobert L Ali

Abstract

This study assessed treatment retention, compliance and completion of a 9-month buprenorphine replacement programme. In addition, changes in drug use and other relevant variables, as well as predictors of completion, were examined. Seventy-five opioid-dependent out-patients (mean age 26 years; 33% females) who aimed for opioid abstinence were enrolled into the study. Assessments were undertaken prior to buprenorphine induction and again at 3, 6 and 9 months. Forty patients (53%) completed the buprenorphine programme. At 9 months, 67 patients (87%) were still in counselling. Mean attendance rates for buprenorphine dosing and counselling sessions were 0.91 and 0.74, respectively. There were significant and persistent reductions in drug use during treatment with, however, a reversed tendency in the 9th month. Psychiatric problems escalated at 9 months, and three patients died during the detoxification phase. Completion was predicted by fewer previous treatment episodes. Detoxification from buprenorphine is associated with substantial psychological distress and an increased death risk. Buprenorphine replacement therapy should be continued until the patient chooses to leave, and close monitoring during the detoxification phase is es...Continue Reading

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Citations

Aug 9, 2007·BMC Psychiatry·Hege Kornør, Hilmar Nordvik
Oct 12, 2015·Drug and Alcohol Dependence·Gerardo GonzalezMonika Kolodziej
Jan 21, 2015·Journal of Substance Abuse Treatment·Brandon S BentzleySarah W Book
Oct 21, 2006·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Wim Van den Brink, Christian Haasen
Apr 30, 2021·Early Intervention in Psychiatry·Jean Nicolas WestenbergReinhard M Krausz

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