ABT737 reverses cisplatin resistance by targeting glucose metabolism of human ovarian cancer cells

International Journal of Oncology
Yunjie XuLiankun Sun

Abstract

The poor prognosis and high mortality of patients with ovarian cancer result in part from their poor response to platinum-based chemotherapy. However, the precise mechanism behind cisplatin resistance is still not fully understood. In the present study, the authors explored the mechanism of resistance to cisplatin from the perspective of glucose metabolism in human ovarian cancer. The experiments using genetically matched ovarian cancer cell lines SKOV3 (cisplatin-sensitive) and SKOV3/DDP (cisplatin-resistant) in the present study provided some important findings. First, in comparison to SKOV3 cells, SKOV3/DDP cells exhibited decreased dependence on aerobic glycolysis and an increased demand for glucose. Secondly, the stable overexpression of Bcl‑2 and ability to shift metabolism towards oxidative phosphorylation (OXPHOS) in SKOV3/DDP cells were associated with increased oxygen consumption. Furthermore, the metabolic characteristic of elevated OXPHOS primarily comprised most mitochondrial‑derived reactive oxygen species (ROS) and, at least in part, contributed to the slight pro-oxidant state of SKOV3/DDP cells in turn. Thirdly, SKOV3/DDP cells reset the redox balance by overexpressing the key enzyme glucose 6-phosphate dehydrog...Continue Reading

Citations

Feb 6, 2020·Mass Spectrometry Reviews·Na Li, Xianquan Zhan
Mar 27, 2020·Frontiers in Oncology·Maria Andrea DesbatsMonica Montopoli
Apr 9, 2020·Frontiers in Pharmacology·Jiabei ZhouLushan Yu
Feb 11, 2020·Frontiers in Oncology·Lisi Ma, Xiangyun Zong
Feb 7, 2020·International Journal of Molecular Sciences·Isabella GiacominiMonica Montopoli
Oct 30, 2020·International Journal of Molecular Sciences·Lanfeng DongJiri Neuzil
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sepideh MirzaeiKwang-Seok Ahn
Jul 13, 2021·Frontiers in Molecular Biosciences·Lude WangJianlie Yuan

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Datasets Mentioned

BETA
ABT737

Methods Mentioned

BETA
profiler
PCR
Protein Assay
Assay
electrophoresis

Software Mentioned

SPSS

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