Abundance of Enterobacteriaceae in the colon mucosa in diverticular disease

World Journal of Gastrointestinal Pathophysiology
Caroline LinningeBodil Ohlsson

Abstract

To compare gut bacterial diversity and amount of Enterobacteriaceae in colonic mucosa between patients with and without diverticular disease (DD). Patients in a stable clinical condition with planned elective colonoscopy were included. Blood samples and colon mucosa biopsies were collected at the colonoscopy. Study questionnaires including questions about gastrointestinal symptoms were completed by the patients and physicians. DNA from mucosa samples was isolated and the amount of Enterobacteriaceae was estimated using PCR assay. Terminal restriction fragment length polymorphism was applied to assess microbial diversity. Diversity was estimated by calculations of richness (number of terminal restriction fragments) and Shannon-Wiener and Simpson's indices. A total of 51 patients were included, 16 patients with DD [68 (62-76) years] and 35 controls [62 (40-74) years] without any diverticula. Patients with DD had significantly higher levels of Enterobacteriaceae than those without DD (P = 0.043), and there was an inverse relationship between the amount of Enterobacteriaceae and the Simpson's index (rs = -0.361, P = 0.033) and the Shannon-Wiener index (rs = -0.299, P = 0.081). The Simpson's index (P = 0.383), Shannon-Wiener index (...Continue Reading

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Citations

Jun 20, 2018·Virology Journal·Lu XiaQian Yang
Jul 9, 2020·International Journal of Molecular Sciences·Noha Ahmed Nasef, Sunali Mehta
Jan 25, 2021·BMC Infectious Diseases·Dangsheng XiaoJiezuan Yang
Jan 8, 2021·International Journal of Colorectal Disease·Aikaterini MastorakiEvangelos Felekouras

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Methods Mentioned

BETA
biopsies

Software Mentioned

SPSS

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