Abundance of mRNA of apolipoprotein b100, apolipoprotein e, and microsomal triglyceride transfer protein in liver from periparturient dairy cows

Journal of Dairy Science
U BernabucciA Nardone

Abstract

Limited secretion of very low density lipoproteins (VLDL) in dairy cows is strongly related to fatty liver and other metabolic disorders in the early postpartum. Currently, there is limited information on which roles apolipoprotein B(100) (ApoB(100)), apolipoprotein E (ApoE), and microsomal triglyceride transfer protein (MTP) play in that VLDL limitation. To our knowledge, no studies have simultaneously measured ApoB(100), ApoE, and MTP mRNA in periparturient dairy cows. Therefore, a trial was conducted to assess liver gene expression of these proteins in transition dairy cows and to evaluate the relationships between their expression and metabolic status. Eight multiparous Holstein cows were monitored during the transition period. To evaluate metabolic and nutritional status, body condition score was registered, and plasma indexes of energy metabolism and VLDL were determined from 35 d before to 35 d after calving. Liver biopsies were performed on d -35, 3, and 35 relative to day of calving, and gene expression of ApoB(100), ApoE, and MTP were determined on liver tissue. Body condition, plasma glucose and VLDL decreased, and plasma NEFA and BHBA increased after calving. Compared with values of d -35, on d 3 after calving the A...Continue Reading

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Citations

Jul 1, 2010·Animal : an International Journal of Animal Bioscience·J J Loor
Nov 26, 2010·International Journal of Biological Sciences·Michael V DodsonZhihua Jiang
May 4, 2016·The British Journal of Nutrition·Arash ShahsavariRafat Al Jassim
Dec 12, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Shixin FuGuowen Liu
May 21, 2005·Journal of Dairy Science·N LaceteraA Nardone
May 1, 2021·Animals : an Open Access Journal From MDPI·Satoshi HagaSanggun Roh

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