PMID: 11341955May 9, 2001Paper

Abundant expression of uncoupling protein-2 in the small intestine: up-regulation by dietary fish oil and fibrates

Biochimica Et Biophysica Acta
T MuraseM Saito

Abstract

Mitochondrial uncoupling protein-2 (UCP-2) is widely expressed in various mammalian tissues, although its physiological functions are not well understood. We examined the effects of dietary fish oil on UCP-2 expression in the rat small intestine, in which UCP-2 mRNA levels are higher than in other organs. Feeding with fish oil (20%) up-regulated UCP-2 mRNA within 6 days in the small intestine as well as the liver, compared to feeding with soybean oil. This was mimicked by feeding with agonists for peroxisome proliferator-activated receptor alpha (PPARalpha) such as fenofibrate and bezafibrate, but not the PPARgamma agonist troglitazone. The bezafibrate-induced increase in UCP-2 expression was found within 2 days in the small intestine, but only after 6 days in the liver. The up-regulation of UCP-2 was also found in cultured intestinal epithelial cells (IEC-6) treated for 24 h with various long-chain fatty acids and PPARalpha agonists. These results indicated that intestinal UCP-2 is up-regulated through direct activation of PPARalpha by dietary fatty acids.

References

Jun 22, 1992·Biochimica Et Biophysica Acta·M E SuretteJ E Kinsella
Jan 1, 1990·Annual Review of Nutrition·P J Nestel
Jul 1, 1986·The British Journal of Nutrition·S C CunnaneD F Horrobin
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·H KellerW Wahli
May 24, 1996·Biochemical and Biophysical Research Communications·A MansénJ A Gustafsson
Dec 1, 1996·Metabolism: Clinical and Experimental·S IkemotoO Ezaki
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·B M FormanR M Evans
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·R S SurwitS Collins
Apr 20, 1999·Biochemical and Biophysical Research Communications·N Tsuboyama-KasaokaO Ezaki
Nov 24, 1999·Biochemical and Biophysical Research Communications·N TuK U Lentes
Jan 6, 2000·The Biochemical Journal·D Ricquier, F Bouillaud
Feb 26, 2000·Journal of Medicinal Chemistry·T M WillsonB R Henke

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Citations

May 15, 2003·Biochemical and Biophysical Research Communications·F RizviR Chander
Nov 14, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Xu-Fang LiangFen Hwang
Jul 20, 2002·The International Journal of Biochemistry & Cell Biology·Petr Jezek
Dec 4, 2003·Best Practice & Research. Clinical Gastroenterology·A ThiesenG Wild
Jan 31, 2003·American Journal of Physiology. Endocrinology and Metabolism·Ji-Ming YeEdward W Kraegen
Aug 29, 2006·World Journal of Gastroenterology : WJG·Laurie Drozdowski, Alan B R Thomson

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