Abundant immunohistochemical expression of dopamine D2 receptor and p53 protein in meningiomas: follow-up, relation to gender, age, tumor grade, and recurrence

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
G TrottM C Oliveira

Abstract

Meningiomas are common, usually benign tumors, with a high postoperative recurrence rate. However, the genesis and development of these tumors remain controversial. We aimed to investigate the presence and implications of a mutated p53 protein and dopamine D2 receptor in a representative series of meningiomas and to correlate these findings with age, gender, tumor grade, and recurrence. Tumor tissue samples of 157 patients diagnosed with meningioma (37 males and 120 females, mean age 53.6 ± 14.3 years) who underwent surgical resection between 2003 and 2012 at our institution were immunohistochemically evaluated for the presence of p53 protein and dopamine D2 receptor and were followed-up to analyze tumor recurrence or regrowth. Tumors were classified as grades I (n=141, 89.8%), II (n=13, 8.3%), or grade III (n=3, 1.9%). Dopamine D2 receptor and p53 protein expression were positive in 93.6% and 49.7% of the cases, respectively. Neither of the markers showed significant expression differences among different tumor grades or recurrence or regrowth statuses. Our findings highlight the potential role of p53 protein in meningioma development and/or progression. The high positivity of dopamine D2 receptor observed in this study warran...Continue Reading

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Citations

Jun 14, 2016·International Journal of Experimental Pathology·Nives Pećina-ŠlausReno Hrašćan
Mar 24, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·B R OngarattiJ F S Pereira-Lima
Jul 15, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Nives Pećina-ŠlausReno Hrašćan
Jul 20, 2016·Cancers·Nives Pećina-ŠlausMirna Lechpammer
Oct 10, 2018·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Lisa CalvocoressiJohn Concato
Aug 26, 2017·Neurosurgical Review·Moncef BerhoumaFrançois Cotton
Sep 10, 2020·Frontiers in Oncology·Gervásio Teles Cardoso de CarvalhoRenata Toscano Simões
Nov 7, 2019·Molecular and Clinical Oncology·Anja BukovacNives Pećina-Šlaus

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Methods Mentioned

BETA
surgical resection
light microscopy

Software Mentioned

Statistical Package for the Social Sciences ( SPSS

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