Abstract
The Controlled Substances Act (CSA) has reduced the diversion of controlled substances at the manufacturing and distribution levels. Recent increased diversion has occurred at the retail level. Levels of diversion and abuse of controlled substances with similar abuse potential and therapeutic indications often parallel availability for medical use, while rates of diversion and abuse may be influenced by factors related to specific products, including their formulations and risk management plans. Abuse deterrent formulations may reduce abuse and attendant adverse health consequences even if the products are diverted. Their development should consider how, to what extent and by whom products containing the targeted substance are abused. It should take into consideration all potential types of abuse including "as is", multiple doses, alternate routes of administration, physical or chemical separation of the active ingredient, compromised extended release mechanisms and abuse in combination with other substances. Industry incentives for developing abuse-resistant formulations include enhanced corporate image and potentially less restrictive scheduling or risk management plans. Scheduling is substance specific, but the CSA includes ...Continue Reading
Citations
Jun 5, 2004·Lab Animal·Angie Lewis, Michael Talcott
Jun 27, 2009·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Jeannette Y Wick
Nov 7, 2014·Expert Opinion on Drug Metabolism & Toxicology·David J Mastropietro, Hossein Omidian
May 14, 2014·Expert Opinion on Drug Delivery·Caroline Victorri-VigneauPhilippe Arnaud
Aug 26, 2009·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Lynn Webster
Sep 22, 2009·Drug and Alcohol Dependence·Jack E Henningfield, Charles R Schuster
Sep 29, 2009·Drug and Alcohol Dependence·Charles R SchusterJack E Henningfield
Oct 22, 2008·Pharmacoepidemiology and Drug Safety·Stephen F ButlerNathaniel Katz
Jul 20, 2007·Pharmacoepidemiology and Drug Safety·Theodore J CiceroAlvaro Munoz
May 14, 2011·Drug and Alcohol Dependence·Briony LaranceDanielle Horyniak
Nov 30, 2013·Pain·Theodore J CiceroSteven P Kurtz
Aug 9, 2011·Thérapie·Sandra NordmannXavier Thirion
Jan 31, 2012·Journal of Drug Issues·Theodore J CiceroJames A Inciardi
Mar 17, 2006·Journal of American College Health : J of ACH·Sean Esteban McCabeCarol J Boyd
Jul 9, 2013·Journal of Child Sexual Abuse·Rachel Lev-Wiesel, Liora Markus
Sep 5, 2021·Sleep·Mike UferJasper Dingemanse