PMID: 18209883Jan 23, 2008Paper

Abuse of anabolic steroids and its impact on thyroid function

Arquivos brasileiros de endocrinologia e metabologia
Rodrigo S FortunatoDenise P de Carvalho

Abstract

The use of anabolic steroids to increase physical performance and for aesthetic ends has reached alarming indices in the last three decades. Besides the desired actions, several collateral effects have been described in the literature, such as the development of some types of cancer, ginecomasty, peliosis hepatis, renal insufficiency, virilization, amongst others. The most proeminent effect on human thyroid function is the reduction of thyroxine binding globulin (TBG), with consequent reductions of total serum T3 and T4, depending however on the susceptibility of the drug to aromatization and subsequent transformation into estrogen. In rats, anabolic steroids also act in the peripheral metabolism of thyroid hormones and seem to exert an important proliferative effect on thyroid cells. Thus, the aim of the present paper is to review data on the effect of supraphysiological doses of anabolic steroids on thyroid function, showing the danger that indiscriminate use of these drugs can cause to health.

References

Oct 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·F Celotti, P Negri Cesi
Nov 1, 1991·American Journal of Obstetrics and Gynecology·W B MalarkeyL M Demers
Jul 1, 1990·Acta Endocrinologica·C H EmersonS L Fang
Jul 1, 1987·The American Journal of Sports Medicine·M AlènR Vihko
Mar 1, 1967·The Journal of Clinical Endocrinology and Metabolism·L E Braverman, S H Ingbar
Feb 1, 1981·Endocrinology·D ChristiansonL E Braverman
May 1, 1995·Sports Medicine·C E Yesalis, M S Bahrke
Feb 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·D W BrannV B Mahesh
Feb 1, 1996·Endocrine Journal·S OhtakiT Kotani
Dec 29, 1995·Molecular and Cellular Endocrinology·K MiyashitaM Mori
Jul 10, 1997·The New England Journal of Medicine·C CaraniE R Simpson
Aug 1, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P C LisbôaC C Pazos-Moura
Aug 27, 1998·The New England Journal of Medicine·J P BilezikianM M Grumbach
Mar 16, 2000·Thyroid : Official Journal of the American Thyroid Association·G C Schussler
Jun 28, 2000·Sports Medicine·M S BahrkeJ A Stephens
Mar 17, 2001·Medicine and Science in Sports and Exercise·W H Joumaa, C Léoty
Jun 28, 2001·Physiological Reviews·P M Yen
Sep 27, 2001·The Journal of Endocrinology·V M da CostaD Rosenthal
Feb 15, 2003·Endocrinology·Cyntia Curcio-MorelliAntonio C Bianco
Dec 22, 2004·Arquivos brasileiros de endocrinologia e metabologia·Mário VaismanDenise P Carvalho
Aug 30, 2005·The Journal of Clinical Investigation·Ana Luiza MaiaP Reed Larsen
Mar 15, 2006·Medicine and Science in Sports and Exercise·Rodrigo S FortunatoDenise P Carvalho
Jan 11, 2007·The Journal of Endocrinology·Michelle P MarassiVânia M Corrêa da Costa
Apr 17, 2007·Arquivos brasileiros de endocrinologia e metabologia·Paulo R P da SilvaMauro A Czepielewski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bartonellosis

Bartonellosis is an infection caused by bacteria in the genus Bartonella and can present as a variety of diseases depending on the organism involved. While asymptomatic infection has been reported, immunocompromised individuals are more susceptible to severe infection. Find the latest research on bartonellosis here.