Abuse of medications that theoretically are without abuse potential

Southern Medical Journal
Roy R ReevesJanet T Laizer

Abstract

The potential for abuse of medications that are controlled substances is well known. Abuse of certain noncontrolled prescription drugs and over-the-counter medications also may occur. To some degree, any medication that exerts psychoactive effects may be abused if taken in high enough doses or by means that result in high serum or cerebrospinal fluid levels. Many clinicians may be unaware of the potential for abuse of these medications. This review examines evidence of the possibility of abuse of several common medications that theoretically do not have abuse potential, including cough and cold preparations, antihistamines, anticholinergics, antipsychotics, antidepressants, anticonvulsants, skeletal muscle relaxants, and antiemetics. Means by which such medications may be abused and biochemical and physiological mechanisms fostering their abuse also are discussed.

References

Mar 26, 2013·Journal of Substance Use·Richard J Cooper

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Citations

May 16, 2017·The American Journal of Nursing·Donna Sabella
Aug 28, 2020·Frontiers in Psychiatry·Stefania ChiappiniFabrizio Schifano
Nov 7, 2019·BJPsych Open·David GoldrichAdam Trenton
Oct 18, 2020·Brain Sciences·Stefania Chiappini, Fabrizio Schifano
Mar 18, 2021·British Journal of Clinical Pharmacology·Princess J OyekanCaroline S Copeland
Nov 7, 2020·Journal of Psychiatric Research·Anees BahjiLouise Good
May 4, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Victor Bassey ArchibongJosiah Eseoghene Ifie
Aug 31, 2021·Substance Abuse : Research and Treatment·Ho Teck TanYit Shiang Lui

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