Abuse Potential of Pregabalin: A Systematic Review

CNS Drugs
Ole SchjerningJimmi Nielsen

Abstract

Several case reports and epidemiological studies have raised concern about the abuse potential of pregabalin, the use of which has increased substantially over the last decade. Pregabalin is, in some cases, used for recreational purposes and it has incurred attention among drug abusers for causing euphoric and dissociative effects when taken in doses exceeding normal therapeutic dosages or used by alternative routes of administration, such as nasal insufflation or venous injection. The magnitude of the abuse potential and the mechanism behind it are not fully known. The aim of this study was to present a systematic review of the data concerning the abuse potential of pregabalin. We performed a systematic literature search and reviewed the preclinical, clinical and epidemiological data on the abuse potential of pregabalin. We included preclinical (n = 17), clinical (n = 19) and epidemiological (n = 13) studies addressing the abuse potential of pregabalin. We also reviewed case reports (n = 9) concerning abuse of pregabalin. The preclinical studies indicated that pregabalin possesses modulatory effects on the GABA and glutamate systems, leaving room for an abuse potential. Further, clinical studies reported euphoria as a frequent...Continue Reading

References

Mar 4, 2003·The American Journal of Psychiatry·Atul C PandeMaria Liu-Dumaw
May 22, 2003·Drug and Alcohol Dependence·Robert L Balster, George E Bigelow
May 22, 2003·Drug and Alcohol Dependence·UNKNOWN Expert Panel
Jun 18, 2003·Seizure : the Journal of the British Epilepsy Association·Laura D Errante, Ognen A C Petroff
Jun 23, 2004·Journal of Clinical Psychopharmacology·Atul C PandeJohn L Werth
Apr 9, 2005·Arthritis and Rheumatism·Leslie J CroffordUNKNOWN Pregabalin 1008-105 Study Group
Apr 14, 2006·Basic & Clinical Pharmacology & Toxicology·Jesper Hallas, Henrik Støvring
Apr 26, 2006·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Howard C BeckerLynn M Veatch
Jun 6, 2008·The Journal of Pain : Official Journal of the American Pain Society·Lesley M ArnoldGeorge Haig
Jul 22, 2008·The Journal of Pain : Official Journal of the American Pain Society·Brett R StaceyMichael C Rowbotham
Jan 31, 2009·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Fatemeh Chalabianloo, Jan Schjøtt
Feb 4, 2010·Neurology·D M SimpsonUNKNOWN 1066 HIV Neuropathy Study Group
Feb 12, 2010·Journal of Clinical Pharmacology·Howard N BockbraderDavid L Wesche
Feb 12, 2010·Nature·Kelly R TanChristian Lüscher
Jul 3, 2010·The American Journal of Psychiatry·Martin GrosshansKarl Mann
Jul 27, 2010·Advances in Pharmacology·Styliani Vlachou, Athina Markou
Sep 8, 2010·Clinical Pharmacokinetics·Howard N BockbraderPaula Burger
Sep 14, 2010·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Jørgen G Bramness
Nov 6, 2010·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Andreas Austgulen Westin, Elin Johanne Hansteen Strøm
Nov 13, 2010·Brain Research·Cathrine BaastrupNanna Brix Finnerup
Feb 10, 2011·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Cecilie Johannessen LandmarkSvein I Johannessen
Apr 23, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Terhi LauniainenIlkka Ojanperä
Jun 21, 2011·Gastroenterology·Søren Schou OlesenAsbjørn Mohr Drewes
Sep 3, 2011·Psychopharmacology·Serena StopponiRoberto Ciccocioppo
Apr 12, 2012·British Journal of Pharmacology·Francisco NavarreteJorge Manzanares
Jun 28, 2012·Addiction Biology·Giordano de GuglielmoRoberto Ciccocioppo
Nov 8, 2012·Advances in Therapy·Riccardo GuglielmoLuigi Janiri
Jan 8, 2013·European Journal of Clinical Pharmacology·Maximilian GahrCarlos Schönfeldt-Lecuona
Mar 23, 2013·Journal of Addiction Medicine·Maximilian GahrCarlos Schönfeldt-Lecuona
Apr 4, 2013·International Journal of Clinical Pharmacology and Therapeutics·Georgios PapazisisDimitrios Kouvelas

❮ Previous
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Citations

Nov 12, 2016·Seizure : the Journal of the British Epilepsy Association·Christian E ElgerChristian Hoppe
Jan 18, 2017·Current Pain and Headache Reports·Eric S Hsu
Jun 20, 2017·British Journal of Biomedical Science·N W Brown
Dec 28, 2017·European Journal of Pain : EJP·S A BuraR Maldonado
Mar 23, 2018·Substance Use & Misuse·Pascal KintzJean-Sébastien Raul
Dec 8, 2017·Drug Testing and Analysis·Federica IanniCristiana Gambelunghe
Jul 20, 2018·Postgraduate Medicine·Srinivas R Nalamachu, Binit Shah
Jul 19, 2018·Expert Opinion on Investigational Drugs·Leigh C Walker, Andrew J Lawrence
Jan 24, 2019·The Cochrane Database of Systematic Reviews·Sheena DerryR Andrew Moore
Dec 24, 2018·British Journal of Clinical Pharmacology·Thitiporn SupasitthumrongSimon J C Davies
Jan 11, 2018·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Kaylee CaniffKristen N Gardner
Feb 10, 2019·British Journal of Clinical Pharmacology·Damien DriotMaryse Lapeyre-Mestre
May 17, 2019·Journal of Analytical Toxicology·Amanda ThompsonAndrew Griffiths
Feb 29, 2020·Journal of Psychoactive Drugs·Mance E Buttram, Steven P Kurtz
Jun 20, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Keke NieYouxin Ji
Aug 29, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Staffan HäggJohan Ahlner
May 12, 2017·Addiction·Abigail LyndonGraeme Henderson
Oct 17, 2019·BMC Emergency Medicine·Marit Mæhle GrimsrudOdd Martin Vallersnes
Mar 3, 2020·Frontiers in Psychiatry·Massimo LanciaCristiana Gambelunghe
Aug 25, 2020·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Patrick Po-Keung KwongKi-Yan Mak
Jun 16, 2018·International Journal of Mental Health and Addiction·Amneh Al-HusseiniMarie Claire Van Hout
Jan 2, 2021·Forensic Science International : Synergy·Nicole S Jones, Jeffrey H Comparin
Dec 11, 2020·The International Journal of Neuropsychopharmacology·Erich SeifritzSiegfried Kasper
Mar 7, 2021·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Craig LeaperUNKNOWN Euro-DEN Plus Research group
Apr 6, 2021·Expert Opinion on Pharmacotherapy·Kalliopi Pafili, Nikolaos Papanas
May 18, 2021·Frontiers in Psychiatry·Francina FonsecaMarta Torrens
Aug 18, 2021·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Shane DarkeJulia Lappin
Dec 22, 2021·Journal of Psychoactive Drugs·Lisa LangluméHélène Peyrière

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