Abyssinone V, a prenylated flavonoid isolated from the stem bark of Erythrina melanacantha increases oxidative stress and decreases stress resistance in Caenorhabditis elegans

The Journal of Pharmacy and Pharmacology
Karoline KochWim Wätjen

Abstract

Recent studies showed that distinct extracts of Erythrina species used in the traditional medicine of sub-Saharan Africa are protective against stress conditions. However, the underlying molecular mechanisms as well as relevant compounds remain unclear. We used the model organism Caenorhabditis elegans to investigate compounds isolated from the stem bark of Erythrina melanacantha (abyssinone V (1), abyssinon-4'O-methylether (2), sigmoidin B-4'O-methylether (3), glabranin (4), 8-prenylnaringenin (5), citflavanone (6), exiguaflavanone (7) and homoeriodictyol (8)). Antioxidative capacity in vitro (trolox equivalent antioxidative capacity assay) and modulation of oxidative stress in vivo (2', 7'-dichlorofluorescein assay) were investigated; stress resistance was analysed using the nucleic acid stain SYTOX green. None of the prenylated flavonoids caused protection against thermal stress; in contrast, most of the compounds (1, 4, 5, 8) decreased stress resistance. None of the compounds decreased the accumulation of reactive oxygen species, but abyssinone V (1) caused an increase in oxidative stress. In line with these results, none of these compounds showed radical-scavenging effects in vitro. The stem bark of E. melanacantha contain...Continue Reading

References

May 1, 1974·Genetics·S Brenner
Apr 23, 2004·Biological Procedures Online·Oscar Zaragoza, Arturo Casadevall
Oct 19, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·W WätjenP Proksch
Jan 9, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A KampkötterR Kahl
Nov 21, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Andreas KampkötterWim Wätjen
Nov 15, 2011·European Journal of Pharmacology·Chantal Beatrice Magne NdeGünter Vollmer
Nov 22, 2011·Pakistan Journal of Biological Sciences : PJBS·Witabouna Mamidou KoneMireille Dosso
Apr 24, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Olugbenga K PopoolaAhmed A Hussein
May 31, 2016·Nutrition·Sascha VenturelliChristian Busch
Jan 9, 2018·Bioscience, Biotechnology, and Biochemistry·Rie Mukai

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Citations

Jan 2, 2021·International Journal of Molecular Sciences·Tania Jiménez-CabreraMinarda De la O-Arciniega
Feb 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kim-Thao LeClaus M Passreiter

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