Acacia ferruginea inhibits inflammation by regulating inflammatory iNOS and COX-2

Journal of Immunotoxicology
Kunnathur Murugesan Sakthivel, Chandrasekaran Guruvayoorappan

Abstract

Inflammation is a local defensive reaction of a host to cellular injury or infection. Prolonged inflammation can contribute to pathogenesis of many disorders. Identification of naturally occurring phytoconstituents that can suppress inflammatory mediators can lead to the discovery of anti-inflammatory therapeutics. Acacia ferruginea is used traditionally to treat numerous ailments including hemorrhage, irritable bowel syndrome and leprosy. The present study evaluated the anti-inflammatory activity of A. ferruginea extract against acute (carrageenan) and chronic (formaldehyde) inflammation in Balb/c mice. Pre-treatment with A. ferruginea extract (10 mg/kg BW) for 5 consecutive days via intraperitonial (IP) administration significantly inhibited subsequent induction of paw edema in both models; the effects were comparable to that of the standard drug indomethacin. The results also showed the A. ferruginea extract significantly inhibited nitric oxide (NO) synthesis and iNOS expression (as measured in serum), diminished inflammation in - and neutrophil infiltration to - the paw tissues and led to a reduction in the number of COX-2(+) immunoreative cells (as evidenced by histologic and immunohistochemical analyses) in the paws relat...Continue Reading

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Citations

Nov 6, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yu QianXin Zhao
May 29, 2019·American Journal of Physical Medicine & Rehabilitation·Yue ZhouDong Liu
Nov 1, 2017·Journal of Nutrition and Metabolism·Douglas S Kalman, Susan J Hewlings

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